ArticleJournal of immunology (Baltimore, Md. : 1950)2018
Syndecan-1 Regulates Psoriasiform Dermatitis by Controlling Homeostasis of IL-17-Producing γδ T Cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Heparan Sulfate Proteoglycans in Immunity.Proteoglycan research · 2026Article
- The extracellular matrix in inflammation and cancer.Molecular biomedicine · 2026Review
- Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis.Cellular & molecular immunology · 2024Article
- Transcriptomes and metabolism define mouse and human MAIT cell populations.Science immunology · 2023Article
- Bioinformatics and Systems Biology Approach to Identify the Pathogenetic Link Between Psoriasis and Cardiovascular Disease.Clinical, cosmetic and investigational dermatology · 2023Article
- Single-cell RNA-seq reveals clonal diversity and prognostic genes of relapsed multiple myeloma.Clinical and translational medicine · 2022Article
- Interleukin-34-regulated T-cell responses in rheumatoid arthritis.Frontiers in medicine · 2022Review
- Extracellular matrix alterations in the skin of patients affected by psoriasis.BMC molecular and cell biology · 2021Article
- CD138 expression is a molecular signature but not a developmental requirement for RORγt+ NKT17 cells.JCI insight · 2021Article
- Interplay between Cell-Surface Receptors and Extracellular Matrix in Skin.Biomolecules · 2020Review
- Barrier lymphocytes in spondyloarthritis.Current opinion in rheumatology · 2020Review
- Lack of Syndecan-1 produces significant alterations in whole-body composition, metabolism and glucose homeostasis in mice.World journal of diabetes · 2020Article
- Syndecans in Inflammation at a Glance.Frontiers in immunology · 2020Review
- Article
- The histopathological landscape of the major psoriasiform dermatoses.Archive of clinical cases · 2019Review
- Unexpected alliance between syndecan-1 and innate-like T cells to protect host from autoimmune effects of interleukin-17.World journal of diabetes · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
IL-17 is a potent proinflammatory cytokine that drives pathogenesis of multiple autoimmune diseases, including psoriasis. A major source of pathogenic IL-17 is a subset of γδ T cells (Tγδ17) that acquires the ability to produce IL-17 while developing in the thymus. The mechanisms that regulate homeostasis of Tγδ17 cells and their roles in psoriasis, however, are not fully understood. In this paper, we show that the heparan sulfate proteoglycan syndecan-1 (sdc1) plays a critical role in regulating homeostasis of Tγδ17 cells and modulating psoriasis-like skin inflammation in mice. sdc1 was predominantly expressed by Tγδ17 cells (but not IL-17
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.