ArticleThe Journal of experimental medicine2018
Tle corepressors are differentially partitioned to instruct CD8
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Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
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Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- Phosphorylation of Runx protein controls helper CD4Nature immunology · 2026Article
- Large-scale meta- and cross-trait analyses uncover shared genetic risk factors for IBS and psychiatric disorders.Frontiers in psychiatry · 2026Article
- Loss of ST8Sia6 mediated α-2,8-linked di-sialylation enhances T cell-dependent antibody responses and promotes autoimmunity in aged mice.Frontiers in immunology · 2026Article
- Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.Journal of advanced research · 2026Article
- Polarization of the memory B-cell response.Journal of leukocyte biology · 2025Review
- Article
- The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8Nature immunology · 2024Article
- The multifaceted roles of TCF1 in innate and adaptive lymphocytes.Advances in immunology · 2024Review
- Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second-generation offspring.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity.Nature immunology · 2023Article
- Tle4 controls both developmental acquisition and early post-natal maturation of corticothalamic projection neuron identity.Cell reports · 2023Article
- Decreased Peripheral Blood Lymphocyte Count Predicts Poor Treatment Response in Peritoneal Dialysis-Associated Peritonitis.Journal of inflammation research · 2023Article
- Host T Cell Dedifferentiation Effects Drive HIV-1 Latency Stability.Journal of virology · 2022Article
- TCF1 in T cell immunity: a broadened frontier.Nature reviews. Immunology · 2022Review
- Roles of transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation.Frontiers in cell and developmental biology · 2022Review
- Transcriptomic analysis revealed increased expression of genes involved in keratinization in the tears of COVID-19 patients.Scientific reports · 2021Article
- The pioneer transcription factors Foxa1 and Foxa2 regulate alternative RNA splicing during thymocyte positive selection.Development (Cambridge, England) · 2021Article
- The prognostic role of the Transducin-like Enhancer of split protein family in lung adenocarcinoma.Translational lung cancer research · 2021Article
- Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons.Cell reports · 2021Article
- Effect of radiotherapy on T cell and PD-1 / PD-L1 blocking therapy in tumor microenvironment.Human vaccines & immunotherapeutics · 2021Review
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Shaojun XingDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA.
Peng ShaoDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA.
Fengyin LiDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA.
Xudong ZhaoDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA.
Wooseok SeoLaboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Justin C WheatDepartment of Pediatrics, Divisions of Medical Genetics and Pediatric Hematology/Oncology, Center for Genetics Research and MGH Cancer Center, Massachusetts General Hospital, Boston, MA.
Selvi RamasamyDepartment of Pediatrics, Divisions of Medical Genetics and Pediatric Hematology/Oncology, Center for Genetics Research and MGH Cancer Center, Massachusetts General Hospital, Boston, MA.
Jianfeng WangDepartment of Pediatrics, Divisions of Medical Genetics and Pediatric Hematology/Oncology, Center for Genetics Research and MGH Cancer Center, Massachusetts General Hospital, Boston, MA.
Xiang LiDepartment of Physics, The George Washington University, Washington, DC.
Weiqun PengDepartment of Physics, The George Washington University, Washington, DC.
Shuyang YuDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA.
Chengyu LiuTransgenic Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-5136-9225
Ichiro TaniuchiLaboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0002-7783-7226
David A SweetserDepartment of Pediatrics, Divisions of Medical Genetics and Pediatric Hematology/Oncology, Center for Genetics Research and MGH Cancer Center, Massachusetts General Hospital, Boston, MA.
Hai-Hui XueDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA hai-hui-xue@uiowa.edu.ORCID 0000-0002-9163-7669
University of Iowa · USMassachusetts General Hospital · USGeorge Washington University · USRIKEN Center for Integrative Medical Sciences · JPNational Institutes of Health · US
Funding
Transgenic CoreZICHL005907 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LIU, CHENGYU · 2010 to 2025
$25.8MTcf/Lef-b-catenin in T cell identity and cancerR01AI112579 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2015 to 2026
$5.4MTcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6MMolecular Analysis of Del(9q) Acute Myeloid LeukemiaR01CA115772 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SWEETSER, DAVID A · 2006 to 2010
$2.0MFlow Cytometry Cell SorterS10OD016199 · OD · UNIVERSITY OF IOWA · PI BALLAS, ZUHAIR K. · 2015 to 2015
$443kMolecular mechanisms controlling differentiation of memory CD8 T cellsR21AI119160 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P, XUE, HAI-HUI · 2015 to 2016
$414kTargeting Tcf/Lef-transcriptional program in leukemic stem cellsI01BX002903 · VA · VA NEW JERSEY HEALTH CARE SYSTEM · PI XUE, HAI-HUI · 2016 to 2019
–BLRD VA I01 BX002903NCI NIH HHS R01 CA115772NIAID NIH HHS R01 AI112579NIAID NIH HHS R01 AI121080NIAID NIH HHS R21 AI119160NIH HHS S10 OD016199
Abstract
Tle/Groucho proteins are transcriptional corepressors interacting with Tcf/Lef and Runx transcription factors, but their physiological roles in T cell development remain unknown. Conditional targeting of Tle1, Tle3 and Tle4 revealed gene dose-dependent requirements for Tle proteins in CD8
Indexed as
Cell LineageAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCore Binding Factor Alpha 3 SubunitCo-Repressor ProteinsGene DeletionMice, Inbred C57BLRepressor ProteinsTranscription FactorsCore Binding Factor Alpha 3 SubunitCo-Repressor ProteinsRepressor ProteinsTle1 protein, mouseTle3 protein, mouseTle4 protein, mouseTranscription Factors
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LicenceCC BY-NC-SA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.