Evidence map›Paper›PMID 30045879›Full record

ArticleGut2019

Human

Eszter Hegyi, Miklós Sahin-Tóth

Open access · greenAbstract read
In one paragraph

Article in Gut, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. MisfoldingAmerican journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
  10. Article
  11. Article
  12. Zoological research · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Misfolding PRSS1 variant p.Ala61Val in a case of suspected intrauterine pancreatitis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2025
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Eszter HegyiCenter for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-9137-7561
Miklós Sahin-TóthCenter for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA.ORCID 0000-0003-4513-9922
Boston University · US

Funding

Molecular Pathomechanism of Hereditary PancreatitisR01DK058088 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAHIN-TOTH, MIKLOS · 2001 to 2019
$5.3M
NIDDK NIH HHS R01 DK058088
6 · The paper itself

Abstract

objectiveChronic pancreatitis is a progressive, relapsing inflammatory disorder of the pancreas, which often develops in the background of genetic susceptibility. Recently, loss-of-function mutations in

designWe knocked-in the most frequently occurring p.N256K human

resultsIn the

conclusionThe results offer categorical evidence that

Indexed as

Protein FoldingAnimalsCarboxypeptidases ADisease Models, AnimalDisease ProgressionEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressGenetic Predisposition to DiseaseHumansMiceMice, Inbred C57BLMice, Mutant StrainsMutationPancreatitis, ChronicCarboxypeptidases AEndoplasmic Reticulum Chaperone BiPHSPA5 protein, humanHspa5 protein, mousepancreatic diseasepancreatic enzymespancreatic fibrosispancreatic pathologypancreatitis

Identifiers

PMID30045879
PMCPMC6326849
OpenAlexW2883629488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.