ArticleProceedings of the National Academy of Sciences of the United States of America2018
Microrheology of DNA hydrogels.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 1 citations in OpenAlex.
- Designing DNA nanostar hydrogels for sequence-specific degradation and antibody release.Soft matter · 2026Article
- Bioengineering DNA-based hydrogels for regenerative medicine: A review of programmable design, chemical synthesis and therapeutic potential.Materials today. Bio · 2026Review
- Mechanically Programmable DNA Hydrogel Microparticles for 3D Cellular Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Unexpected strong paramagnetism of hydrogels containing carbon-oxygen double bonds induced by calcium cations.Nature materials · 2026Article
- Design and Characterization of DX-Tile DNA Nanostar-Based Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Theory for sequence selection via phase separation and oligomerization.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mechanically Tunable DNA Hydrogels as Prospective Biosensing Modules.Macromolecular rapid communications · 2025Article
- Role of Charge Patterning and Hydrophobicity in Peptide-Based Complex Coacervates.Biomacromolecules · 2025Article
- Topological linking determines elasticity in limited valence networks.Nature materials · 2025Article
- Microrheological study on the entanglement dynamics of salt-free polyelectrolyte solutions in the semidilute entangled regime.Polymer journal · 2025Article
- DNA microbeads for spatio-temporally controlled morphogen release within organoids.Nature nanotechnology · 2024Article
- Viscoelasticity in 3D Cell Culture and Regenerative Medicine: Measurement Techniques and Biological Relevance.ACS materials Au · 2024Review
- Article
- HowmBio · 2024Article
- Dynamic control of DNA condensation.Nature communications · 2024Article
- Fully angularly resolved 3D microrheology with optical tweezers.Rheologica acta · 2024Article
- Programmable all-DNA hydrogels based on rolling circle and multiprimed chain amplification products.APL bioengineering · 2023Article
- Dynamic matrices with DNA-encoded viscoelasticity for cell and organoid culture.Nature nanotechnology · 2023Article
- Sequence self-selection by cyclic phase separation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Simultaneous Nanorheometry and Nanothermometry Using Intracellular Diamond Quantum Sensors.ACS nano · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A key objective in DNA-based material science is understanding and precisely controlling the mechanical properties of DNA hydrogels. We perform microrheology measurements using diffusing wave spectroscopy (DWS) to investigate the viscoelastic behavior of a hydrogel made of Y-shaped DNA (Y-DNA) nanostars over a wide range of frequencies and temperatures. We observe a clear liquid-to-gel transition across the melting temperature region for which the Y-DNA bind to each other. Our measurements reveal a cross-over between the elastic [Formula: see text] and loss modulus [Formula: see text] around the melting temperature [Formula: see text] of the DNA building blocks, which coincides with the systems percolation transition. This transition can be easily shifted in temperature by changing the DNA bond length between the Y shapes. Using bulk rheology as well, we further show that, by reducing the flexibility between the Y-DNA bonds, we can go from a semiflexible transient network to a more energy-driven hydrogel with higher elasticity while keeping the microstructure the same. This level of control in mechanical properties will facilitate the design of more sensitive molecular sensing tools and controlled release systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.