ArticleAlzheimer's research & therapy2018
Retained capacity for perceptual learning of degraded speech in primary progressive aphasia and Alzheimer's disease.
Article in Alzheimer's research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Speech-In-Noise Perception in Alzheimer's Disease and Primary Progressive Aphasia.European journal of neurology · 2026Article
- Non-verbal dichotic listening: A new cognitive hearing test for dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neural and Behavioral Predictors of Speech Motor Sequence Learning in Primary Progressive Aphasia.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Article
- Clinical Manifestations and Neural Basis of Semantic Dementia: Converging Evidences From Brain Imaging Studies.Clinical interventions in aging · 2025Review
- Comprehension of acoustically degraded emotional prosody in Alzheimer's disease and primary progressive aphasia.Scientific reports · 2024Article
- Speech perception and language comprehension in primary progressive aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Primary progressive aphasia: six questions in search of an answer.Journal of neurology · 2024Review
- Comprehension of acoustically degraded speech in Alzheimer's disease and primary progressive aphasia.Brain : a journal of neurology · 2023Article
- Symptom-led staging for primary progressive aphasia.medRxiv : the preprint server for health sciences · 2023Article
- Article
- Causal Contributions of the Domain-General (Multiple Demand) and the Language-Selective Brain Networks to Perceptual and Semantic Challenges in Speech Comprehension.Neurobiology of language (Cambridge, Mass.) · 2022Article
- Phonemic restoration in Alzheimer's disease and semantic dementia: a preliminary investigation.Brain communications · 2022Article
- Processing of Degraded Speech in Brain Disorders.Brain sciences · 2021Review
- Hearing and dementia: from ears to brain.Brain : a journal of neurology · 2021Review
- Primary Progressive Aphasia: Toward a Pathophysiological Synthesis.Current neurology and neuroscience reports · 2021Review
- Impairments of auditory scene analysis in posterior cortical atrophy.Brain : a journal of neurology · 2020Article
- Impaired phonemic discrimination in logopenic variant primary progressive aphasia.Annals of clinical and translational neurology · 2020Article
- Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Can Script Training Improve Narrative and Conversation in Aphasia across Etiology?Seminars in speech and language · 2020Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundProcessing of degraded speech is a promising model for understanding communication under challenging listening conditions, core auditory deficits and residual capacity for perceptual learning and cerebral plasticity in major dementias.
methodsWe compared the processing of sine-wave-degraded speech in 26 patients with primary progressive aphasia (non-fluent, semantic, and logopenic variants), 10 patients with typical Alzheimer's disease and 17 healthy control subjects. Participants were required to identify sine-wave words that were more predictable (three-digit numbers) or less predictable (place names). The change in identification performance within each session indexed perceptual learning. Neuroanatomical associations of degraded speech processing were assessed using voxel-based morphometry.
resultsPatients with non-fluent and logopenic progressive aphasia and typical Alzheimer's disease showed impaired identification of sine-wave numbers, whereas all syndromic groups showed impaired identification of sine-wave place names. A significant overall identification advantage for numbers over place names was shown by patients with typical Alzheimer's disease, patients with semantic progressive aphasia and healthy control participants. All syndromic groups showed spontaneous perceptual learning effects for sine-wave numbers. For the combined patient cohort, grey matter correlates were identified across a distributed left hemisphere network extending beyond classical speech-processing cortices.
conclusionsThese findings demonstrate resilience of auditory perceptual learning capacity across dementia syndromes, despite variably impaired perceptual decoding of degraded speech and reduced predictive integration of semantic knowledge. This work has implications for the neurobiology of dynamic sensory processing and plasticity in neurodegenerative diseases and for development of novel biomarkers and therapeutic interventions.
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