ArticleMicrobial cell factories2018
Enhanced biosynthesis of phenazine-1-carboxamide by engineered Pseudomonas chlororaphis HT66.
Article in Microbial cell factories, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 71 citations in OpenAlex.
- Multilayer microcapsules improved the tolerance to adverse conditions of Pseudomonas aeruginosa A14 and biocontrol effect against cabbage Fusarium wilt.Pest management science · 2026Article
- Pseudomonas spp. and antimicrobial resistance: unlocking new horizons with 1-hydroxyphenazine.Folia microbiologica · 2025Review
- Investigation of the mechanisms involved in the biocontrol activities of natural products from a marine soil bacterium against rice blast.Pest management science · 2025Article
- Global Gac/Rsm regulatory system activates the biosynthesis of mupirocin by controlling the MupR/I quorum sensing system inApplied and environmental microbiology · 2025Article
- Screening of natural phenazine producers for electroactivity in bioelectrochemical systems.Microbial biotechnology · 2023Article
- Recent Developments in the Biological Activities, Bioproduction, and Applications ofMolecules (Basel, Switzerland) · 2023Review
- Biosynthesis and genetic engineering of phenazine-1-carboxylic acid inFrontiers in microbiology · 2023Article
- Making "Sense" of Ecology from a Genetic Perspective:Metabolites · 2022Review
- Article
- Characteristics of biological control and mechanisms of Pseudomonas chlororaphis zm-1 against peanut stem rot.BMC microbiology · 2022Article
- Recent Advances and Opportunities in the Study ofFrontiers in cellular and infection microbiology · 2022Review
- Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies.Marine drugs · 2021Review
- Genetic engineering of Pseudomonas chlororaphis Lzh-T5 to enhance production of trans-2,3-dihydro-3-hydroxyanthranilic acid.Scientific reports · 2021Article
- Isolation and Characterization ofPlants (Basel, Switzerland) · 2021Article
- Xylose-Inducible Promoter Tools forApplied and environmental microbiology · 2020Article
- Identification of new arylamine N-acetyltransferases and enhancing 2-acetamidophenol production in Pseudomonas chlororaphis HT66.Microbial cell factories · 2020Article
- Recent Progress in Lab-On-a-Chip Systems for the Monitoring of Metabolites for Mammalian and Microbial Cell Research.Sensors (Basel, Switzerland) · 2019Review
- Electricigens in the anode of microbial fuel cells: pure cultures versus mixed communities.Microbial cell factories · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPhenazine-1-carboxamide (PCN), a phenazine derivative, is strongly antagonistic to fungal phytopathogens. The high PCN biocontrol activity fascinated researcher's attention in isolating and identifying novel bacterial strains combined with engineering strategies to target PCN as a lead molecule. The chemical route for phenazines biosynthesis employs toxic chemicals and display low productivities, require harsh reaction conditions, and generate toxic by-products. Phenazine biosynthesis using some natural phenazine-producers represent remarkable advantages of non-toxicity and possibly high yield in environmentally-friendlier settings.
resultsA biocontrol bacterium with antagonistic activity towards fungal plant pathogens, designated as strain HT66, was isolated from the rice rhizosphere. The strain HT66 was identified as Pseudomonas chlororaphis based on the colony morphology, gas chromatography of cellular fatty acids and 16S rDNA sequence analysis. The secondary metabolite produced by HT66 strain was purified and identified as PCN through mass spectrometry, and
conclusionIn conclusion, the results evidence that P. chlororaphis HT66 could be modified as a potential cell factory for industrial-scale biosynthesis of PCN and other phenazine derivatives by metabolic engineering strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.