Evidence map›Paper›PMID 30045617›Full record

ArticleJournal of the American Chemical Society2018

C-H Functionalization of Amines via Alkene-Derived Nucleophiles through Cooperative Action of Chiral and Achiral Lewis Acid Catalysts: Applications in Enantioselective Synthesis.

Ming Shang, Jessica Z Chan, Min Cao, Yejin Chang, Qifan Wang, Brennan Cook, Sebastian Torker, Masayuki Wasa

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 123 citations in OpenAlex.

  1. Skeletal Reorganization of Cycloalkylamines Into Angular Azatetracyclic Scaffolds.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Desymmetrization ofJournal of the American Chemical Society · 2026
    Article
  3. Asymmetric Hydride Shift Reactions Catalyzed by Chiral Aluminium Complexes.Angewandte Chemie (International ed. in English) · 2026
    Article
  4. B(COrganic letters · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Asian journal of organic chemistry · 2023
    Article
  11. Article
  12. Review
  13. Reactions of Diethylazo-Dicarboxylate with Frustrated Lewis Pairs.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Consecutive β,β'-Selective C(spAngewandte Chemie (International ed. in English) · 2021
    Article
  18. Article
  19. Enantioselective Synthesis ofJournal of the American Chemical Society · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ming ShangDepartment of Chemistry, Merkert Chemistry Center , Boston College , Chestnut Hill , Massachusetts 02467 , United States.ORCID 0000-0002-0785-8427
Jessica Z ChanDepartment of Chemistry, Merkert Chemistry Center , Boston College , Chestnut Hill , Massachusetts 02467 , United States.
Min CaoDepartment of Chemistry, Merkert Chemistry Center , Boston College , Chestnut Hill , Massachusetts 02467 , United States.
Yejin ChangDepartment of Chemistry, Merkert Chemistry Center , Boston College , Chestnut Hill , Massachusetts 02467 , United States.
Qifan WangDepartment of Chemistry, Merkert Chemistry Center , Boston College , Chestnut Hill , Massachusetts 02467 , United States.
Brennan CookDepartment of Chemistry, Merkert Chemistry Center , Boston College , Chestnut Hill , Massachusetts 02467 , United States.
Sebastian TorkerDepartment of Chemistry, Merkert Chemistry Center , Boston College , Chestnut Hill , Massachusetts 02467 , United States.
Masayuki WasaDepartment of Chemistry, Merkert Chemistry Center , Boston College , Chestnut Hill , Massachusetts 02467 , United States.ORCID 0000-0002-3309-9129
Boston College · US

Funding

Catalytic and Stereoselective C-C-Heteroatom Bond Forming ReactionsR35GM128695 · NIGMS · UNIVERSITY OF FLORIDA · PI Masayuki Wasa · 2018 to 2026
$3.8M
NIGMS NIH HHS R35 GM128695
6 · The paper itself

Abstract

Catalytic transformations of α-amino C-H bonds to afford valuable enantiomerically enriched α-substituted amines, entities that are prevalent in pharmaceuticals and bioactive natural products, have been developed. Typically, such processes are carried out under oxidative conditions and require precious metal-based catalysts. Here, we disclose a strategy for an enantioselective union of N-alkylamines and α,β-unsaturated compounds, performed under redox-neutral conditions, and promoted through concerted action of seemingly competitive Lewis acids, B(C

Indexed as

AlkenesAminesCatalysisLewis AcidsOxidation-ReductionStereoisomerismAlkenesAminesLewis Acids

Identifiers

PMID30045617
PMCPMC6542567
OpenAlexW2883020712

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.