ArticleBiochimica et biophysica acta. Molecular and cell biology of lipids2018
Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii.
Article in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Promising Drug Repurposing Candidates Targeting Free-Living Amoebae: A Systematic and Critical Review of Laboratory-Based Evidence.Pathogens (Basel, Switzerland) · 2026Pooled it
- Benzophenone Derivatives as a New Class of Anti-Infectives Against Acanthamoeba spp.Archiv der Pharmazie · 2026Article
- Review
- Navigating the Challenges of Acanthamoeba Keratitis: Current Trends and Future Directions.Life (Basel, Switzerland) · 2025Review
- Azole-based compounds as potential anti-RSC medicinal chemistry · 2024Article
- Self-assembled micelles loaded with itraconazole as anti-Acanthamoeba nano-formulation.Archives of microbiology · 2024Article
- Druggable Sterol Metabolizing Enzymes in Infectious Diseases: Cell Targets to Therapeutic Leads.Biomolecules · 2024Review
- Steroidal Antimetabolites Protect Mice againstMolecules (Basel, Switzerland) · 2022Article
- The Fate of Bacteria of the Bacillus cereus Group in the Amoeba Environment.Microbial ecology · 2022Article
- Drug discovery for primary amebic meningoencephalitis: from screen to identification of leads.Expert review of anti-infective therapy · 2021Article
- In Vitro Effect of Pitavastatin and Its Synergistic Activity with Isavuconazole againstPathogens (Basel, Switzerland) · 2020Article
- The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii.Antimicrobial agents and chemotherapy · 2020Article
- Identification of Four Amoebicidal Nontoxic Compounds by a Molecular Docking Screen ofACS infectious diseases · 2019Article
- A gas chromatography-mass spectrometry-based whole-cell screening assay for target identification in distal cholesterol biosynthesis.Nature protocols · 2019Article
- Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications.Journal of lipid research · 2019Article
- Microbial Sterolomics as a Chemical Biology Tool.Molecules (Basel, Switzerland) · 2018Review
- Metabolic Profile Associated With Encystation in Acanthamoeba.The Journal of eukaryotic microbiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
The sterol metabolome of Acanthamoeba castellanii (Ac) yielded 25 sterols. Substrate screening of cloned AcCYP51 revealed obtusifoliol as the natural substrate which converts to ∆
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.