ArticlePloS one2018
Chronic irradiation with 222-nm UVC light induces neither DNA damage nor epidermal lesions in mouse skin, even at high doses.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Managing infectious aerosols to counter engineered pandemics: Current recommendations and future research.Risk analysis : an official publication of the Society for Risk Analysis · 2025Guideline
- The efficacy of ultraviolet light-emitting technology against coronaviruses: a systematic review.The Journal of hospital infection · 2021Pooled it
- Evaluation of ultraviolet irradiation at 254 nm and 222 nm in inactivating human noroviruses on surfaces.Applied and environmental microbiology · 2026Article
- Subchronic toxicity of 222 nm ultraviolet irradiation in rats for safe human translation and application guidelines.Scientific reports · 2026Article
- Antimicrobial Effect of Ultraviolet C (UV-C) Light Compared to Standard Povidone-Iodine Protocol for Preoperative Disinfection of the Periocular Area.Veterinary ophthalmology · 2026Article
- Design of 222 nm UV-C experimental device and experiment on the effect of radiation on the quality of post-harvested fresh tomatoes.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- Novel treatment of infectious keratitis in canine corneas using ultraviolet C (UV-C) light.Veterinary ophthalmology · 2025Article
- Dermatological effects of acute and long-term UV-C exposure: an in vivo study using a portable mercury lamp.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- Far-ultraviolet light causes direct DNA damage in human lung cells and tissues.Scientific reports · 2025Article
- Wavelength-dependent DNA damage induced by single wavelengths of UV-C radiation (215 to 255 nm) in a human cornea model.Scientific reports · 2025Article
- Article
- Wavelength-Dependent DNA Damage Induced by Single Wavelengths of UVC Light (215 to 255 nm) in a Human Cornea Model.Research square · 2024Article
- Investigations on the surface disinfection efficacy of far-UVC 222 nm germicidal irradiance device in a controlled environment and field test.Journal of environmental health science & engineering · 2024Article
- Human exposure to air contaminants under the far-UVC system operation in an office: effects of lamp position and ventilation condition.Scientific reports · 2024Article
- The Antibacterial Efficacy of Far-UVC Light: A Combined-Method Study Exploring the Effects of Experimental and Bacterial Variables on Dose-Response.Pathogens (Basel, Switzerland) · 2024Article
- Effects of 222 nm Germicidal Ultraviolet Light on Aerosol and VOC Formation from Limonene.ACS ES&T air · 2024Article
- The new 222-nm far ultraviolet-C lowers bacterial contamination to endoscopists during esophagogastroduodenoscopy.DEN open · 2024Article
- Research progress on environmental stability of SARS-CoV-2 and influenza viruses.Frontiers in microbiology · 2024Review
- Bactericidal effect of far ultraviolet-C irradiation at 222 nm against bacterial peritonitis.PloS one · 2024Article
- Intermittent low-dose far-UVC irradiation inhibits growth of common mold below threshold limit value.PloS one · 2024Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgical site infections (SSIs) represent an important clinical problem associated with increased levels of surgical morbidity and mortality. UVC irradiation during surgery has been considered to represent a possible strategy to prevent the development of SSI. 254-nm UVC induces marked levels of DNA damage by generating cyclobutyl pyrimidine dimers (CPD) in microorganisms. However, this effect is elicited not only in microorganisms, but also in human cells, and chronic exposure to 254-nm UVC has been established to represent a human health hazard. In contrast, despite short wavelength-UVC light, especially 222-nm UVC, having been demonstrated to elicit a bactericidal effect, single irradiation with a high dose of 222-nm UVC energy has been reported to not induce mutagenic or cytotoxic DNA lesions in mammalian cells. However, the effect of chronic irradiation with a high dose of 222-nm UVC to mammalian cells has not been determined. In this study, it was demonstrated that large numbers of CPD-expressing cells were induced in the epidermis of mice following treatment with a small amount of single exposure 254-nm UVC, and then less than half of these cells reduced within 24 h. Chronic 254-nm UVC irradiation was revealed to induce sunburn and desquamation in mouse skin. Histological analysis demonstrated that small numbers of CPD-expressing cells were detected only in hyperkeratotic stratum corneum after chronic irradiation with a high dose of 254-nm UVC, and that significant hyperplasia and intercellular edema were also induced in the epidermis of mice. In contrast, chronic irradiation with 222-nm UVC light was revealed not to induce mutagenic or cytotoxic effects in the epidermis of mice. These results indicated that 222-nm UVC light emitted from the lamp apparatus (or device), which was designed to attenuate harmful light present in wavelengths of more than 230 nm, represents a promising tool for the reduction of SSI incidence in patients and hospital staff.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.