ArticlePloS one2018
TCRβ-expressing macrophages induced by a pathogenic murine malaria correlate with parasite burden and enhanced phagocytic activity.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- MyD88-mediated chimaeric antigen receptor macrophages suppress brain metastasis using target-specific phagocytosis.Nature biomedical engineering · 2026Article
- Emerging Role of Splenic Macrophage in Malaria Pathogenesis and Immunity.Immunity, inflammation and disease · 2025Review
- Potential role of liver-resident CD3JHEP reports : innovation in hepatology · 2025Article
- Enrichment of novel CD3+F4/80+ cells in brown adipose tissue following adrenergic stimulation.Frontiers in immunology · 2024Article
- Effects of anti-tau immunotherapy on reactive microgliosis, cerebral endotheliopathy, and cognitive function in an experimental model of cerebral malaria.Journal of neurochemistry · 2023Article
- T-cell receptor αβImmunology and cell biology · 2023Article
- Review
- Murine RAW Macrophages Are a Suitable Model to Study the CD3 Signaling in Myeloid Cells.Cells · 2022Article
- Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen.Hernia : the journal of hernias and abdominal wall surgery · 2022Article
- Single-cell RNA sequencing reveals TCRFrontiers in immunology · 2022Article
- JEV Infection Induces M-MDSC Differentiation Into CD3Frontiers in immunology · 2022Article
- Trilineage Sequencing Reveals Complex TCRβ Transcriptomes in Neutrophils and Monocytes Alongside T Cells.Genomics, proteomics & bioinformatics · 2021Article
- PET Imaging of Translocator Protein as a Marker of Malaria-Associated Lung Inflammation.Infection and immunity · 2021Article
- Factors influencing phagocytosis of malaria parasites: the story so far.Malaria journal · 2021Review
- RNA Flow Cytometry for the Study of T Cell Metabolism.International journal of molecular sciences · 2021Review
- Article
- Renal double negative T cells: unconventional cells in search of a function.Annals of translational medicine · 2019Article
- Circulating monocytes and tumor-associated macrophages express recombined immunoglobulins in glioblastoma patients.Clinical and translational medicine · 2019Article
- Myeloid cell TNFR1 signaling dependent liver injury and inflammation upon BCG infection.Scientific reports · 2019Article
- CD3Frontiers in immunology · 2019Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
Macrophages express a wide array of invariant receptors that facilitate host defense and mediate pathogenesis during pathogen invasion. We report on a novel population of CD11bhighCD14+F4/80+ macrophages that express TCRβ. This population expands dramatically during a Plasmodium berghei ANKA infection and sequesters in the brain during experimental cerebral malaria. Importantly, measurement of TCRβ transcript and protein levels in macrophages in wildtype versus nude and Rag1 knockout mice establishes that the observed expression is not a consequence of passive receptor expression due to phagocytosis or trogocytosis of peripheral T cells or nonspecific antibody staining to an Fc receptor or cross reactive epitope. We also demonstrate that TCRβ on brain sequestered macrophages undergoes productive gene rearrangements and shows preferential Vβ usage. Remarkably, there is a significant correlation in the proportion of macrophages that express TCRβ and peripheral parasitemia. In addition, presence of TCRβ on the macrophage also correlates with a significant increase (1.9 fold) in the phagocytosis of parasitized erythrocytes. By transcriptional profiling, we identify a novel set of genes and pathways that associate with TCRβ expression by the macrophage. Expansion of TCRβ-expressing macrophages points towards a convergence of the innate and adaptive immune responses where both arms of the immune system cooperate to modulate the host response to malaria and possibly other infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.