Evidence map›Paper›PMID 30044780›Full record

ArticlePLoS neglected tropical diseases2018

Scabies and risk of skin sores in remote Australian Aboriginal communities: A self-controlled case series study.

Phyo Thu Zar Aung, Will Cuningham, Kerry Hwang, Ross M Andrews, Jonathan R Carapetis, Therese Kearns, Danielle Clucas, Jodie McVernon, Julie Ann Simpson, Steven Y C Tong and 1 more

Open access · goldAbstract read
In one paragraph

Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Scabies: Epidemiology, Diagnosis, and Treatment.Deutsches Arzteblatt international · 2021
    Review
  9. Paediatrics: how to manage scabies.Drugs in context · 2021
    Review
  10. Review
  11. Article
  12. Review
  13. Control Strategies for Scabies.Tropical medicine and infectious disease · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Phyo Thu Zar AungVictorian Infectious Disease Reference Laboratory, The Royal Melbourne Hospital and The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0001-8441-1920
Will CuninghamVictorian Infectious Disease Reference Laboratory, The Royal Melbourne Hospital and The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Kerry HwangMelbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-5875-8493
Ross M AndrewsMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Jonathan R CarapetisTelethon Kids Institute, University of Western Australia and Perth Children's Hospital, Perth, Western Australia, Australia.
Therese KearnsMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.ORCID 0000-0003-0862-7572
Danielle ClucasDepartment of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia.
Jodie McVernonVictorian Infectious Disease Reference Laboratory, The Royal Melbourne Hospital and The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Julie Ann SimpsonMelbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Steven Y C TongMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Patricia Therese CampbellVictorian Infectious Disease Reference Laboratory, The Royal Melbourne Hospital and The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0003-4013-9835
The Royal Melbourne Hospital · AUThe University of Melbourne · AUAustralian National University · AUCharles Darwin University · AUThe Kids Research Institute Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkin sores caused by Group A streptococcus (GAS) infection are a major public health problem in remote Aboriginal communities. Skin sores are often associated with scabies, which is evident in scabies intervention programs where a significant reduction of skin sores is seen after focusing solely on scabies control. Our study quantifies the strength of association between skin sores and scabies among Aboriginal children from the East Arnhem region in the Northern Territory. METHODS AND

resultsPre-existing datasets from three published studies, which were conducted as part of the East Arnhem Healthy Skin Project (EAHSP), were analysed. Aboriginal children were followed from birth up to 4.5 years of age. Self-controlled case series design was used to determine the risks, within individuals, of developing skin sores when infected with scabies versus when there was no scabies infection. Participants were 11.9 times more likely to develop skin sores when infected with scabies compared with times when no scabies infection was evident (Incidence Rate Ratio (IRR) 11.9; 95% CI 10.3-13.7; p<0.001), and this was similar across the five Aboriginal communities. Children had lower risk of developing skin sores at age ≤1 year compared to at age >1 year (IRR 0.8; 95% CI 0.7-0.9).

conclusionThe association between scabies and skin sores is highly significant and indicates a causal relationship. The public health importance of scabies in northern Australia is underappreciated and a concerted approach is required to recognise and eliminate scabies as an important precursor of skin sores.

Indexed as

AnimalsCase-Control StudiesChild, PreschoolCohort StudiesFemaleHumansImpetigoInfantMaleNorthern TerritorySarcoptes scabieiScabiesSkinStreptococcal InfectionsStreptococcus

Identifiers

PMID30044780
PMCPMC6078322
OpenAlexW2884802658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.