Evidence map›Paper›PMID 30044555›Full record

ArticleAdvanced healthcare materials2018

3D-Plotted Beta-Tricalcium Phosphate Scaffolds with Smaller Pore Sizes Improve In Vivo Bone Regeneration and Biomechanical Properties in a Critical-Sized Calvarial Defect Rat Model.

Jingjing Diao, Jun OuYang, Ting Deng, Xiao Liu, Yanting Feng, Naru Zhao, Chuanbin Mao, Yingjun Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 102 citations in OpenAlex.

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  9. Biomineral-Based Composite Materials in Regenerative Medicine.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Jingjing DiaoSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Jun OuYangDepartment of Anatomy, Guangdong Provincial Key Laboratory of Medical Biomechanics, Southern Medical University, Guangzhou, 510515, China.
Ting DengDepartment of Anatomy, Guangdong Provincial Key Laboratory of Medical Biomechanics, Southern Medical University, Guangzhou, 510515, China.
Xiao LiuSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Yanting FengDepartment of Anatomy, Guangdong Provincial Key Laboratory of Medical Biomechanics, Southern Medical University, Guangzhou, 510515, China.
Naru ZhaoSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Chuanbin MaoDepartment of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, Institute for Biomedical Engineering, Science and Technology, University of Oklahoma, 101 Stephenson Parkway, Room 3310, Norman, OK, 73019-5300, USA.ORCID 0000-0002-8142-3659
Yingjun WangSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Key Laboratory of Guangdong Province · CNSouthern Medical University · CNZhejiang University · CN

Funding

Hiring Non-toxic Virus Nanoparticles to Count Cancer Biomarker MoleculesR21CA195607 · NCI · UNIVERSITY OF OKLAHOMA · PI MAO, CHUANBIN · 2015 to 2016
$359k
National key R&D Program of China 2016YFA0100900National key R&D Program of China 2017YFC1105000National Natural Science Foundation of China 31700823National Natural Science Foundation of China 51673168NCI NIH HHS R21 CA195607NIH HHS CA195607Science and Technology program of Guangdong Province 2017B030314008Science and Technology program of Guangdong Province 2017B090911008Science and Technology Program of Guangzhou City 201607010234
6 · The paper itself

Abstract

Due to the difficulty in fabricating bioceramic scaffolds with smaller pore sizes by the current 3D printing technique, the effect of smaller pore sizes (below 400 µm) of 3D printed bioceramic scaffolds on the bone regeneration and biomechanical behavior is never studied. Herein beta-tricalcium phosphate (β-TCP) scaffolds with interconnected smaller pores of three different sizes (100, 250, and 400 µm) are fabricated by 3D plotting. The resultant scaffolds are then implanted into rat critical-sized calvarial defects without any seeded cells. A custom-designed device is developed to investigate the biomechanical properties of the scaffolds after surgical implantation for 4, 8, and 12 weeks. The scaffolds with the 100 µm pore size are found to present the highest maximum load and stiffness, comparable to those of the autogenous bone, after being implanted for 12 weeks. Micro-computed tomography (micro-CT) and histological analysis further indicate that the scaffolds with the 100 µm pore size achieve the highest percentage of new bone ingrowth, which correlates to their best in vivo biomechanical properties. This study demonstrates that tailoring the pore size of β-TCP scaffolds to a smaller range by 3D-plotting can be a facile and efficient approach to enhanced bone regeneration and biomechanical behaviors in bone repair.

Indexed as

AnimalsBone RegenerationBone SubstitutesCalcium PhosphatesCell ProliferationCells, CulturedMiceOsteogenesisPorosityPrinting, Three-DimensionalRatsTissue Scaffoldsbeta-tricalcium phosphateBone SubstitutesCalcium Phosphates3D plottingbiomechanical propertiesbonespore sizesβ-TCP scaffolds

Identifiers

PMID30044555
PMCPMC6355155
OpenAlexW2883996592

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.