ArticleArthritis care & research2019
Antinuclear Antibody-Negative Systemic Lupus Erythematosus in an International Inception Cohort.
Article in Arthritis care & research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 93 citations in OpenAlex.
- Case Report: A case of neuropsychiatric lupus with primary central nervous system diffuse large B-cell lymphoma.Frontiers in immunology · 2025Article
- Full-house nephropathy in antinuclear antibody-negative systemic lupus erythematosus: A case report.Clinical case reports · 2024Article
- A Clinical Picture of Unselected Patients with Systemic Lupus Erythematosus in a Tertiary Hungarian Center-A Spectrum Ranging from Pure Lupus to Overlap Syndromes.Journal of clinical medicine · 2024Article
- Autoantibody phenotyping of antinuclear antibody-negative systemic lupus erythematosus patients.Archives of rheumatology · 2024Article
- Why is it so difficult to understand why we don't understand human systemic lupus erythematosus? Contemplating facts, conflicts, and impact of "the causality cascade paradigm".Frontiers in immunology · 2024Review
- Advances in Diagnosis and Therapeutics in Recurrent Autoimmune Pericarditis in Pregnancy.JACC. Case reports · 2023Article
- Article
- ANA-negative severe lupus-like presentation: Is it lupus or not?Clinical case reports · 2023Article
- Identification and assessment of classification criteria attributes for systemic lupus erythematosus in a regional medical record data network.Lupus science & medicine · 2023Article
- Negative ANA-IIF in SLE patients: what is beyond?Clinical rheumatology · 2023Article
- Antinuclear antibody-negative systemic lupus erythematosus: How many patients and how to identify?Archives of rheumatology · 2022Article
- Article
- Rising incidence and prevalence of systemic lupus erythematosus: a population-based study over four decades.Annals of the rheumatic diseases · 2022Article
- Longitudinal analysis of ANA in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort.Annals of the rheumatic diseases · 2022Article
- Cytokine autoantibodies in SARS-CoV-2 prepandemic and intrapandemic samples from an SLE cohort.Lupus science & medicine · 2022Article
- [Systemic lupus erythematosus-are children small adults?]Zeitschrift fur Rheumatologie · 2022Review
- Salivary anti-nuclear antibody (ANA) mirrors serum ANA in systemic lupus erythematosus.Arthritis research & therapy · 2022Article
- Anti-Nuclear Antibodies Patterns in Patients With Systemic Lupus Erythematosus and Their Correlation With Other Diagnostic Immunological Parameters.Frontiers in immunology · 2022Article
- SLE classification criteria: Science-based icons or algorithmic distractions - an intellectually demanding dilemma.Frontiers in immunology · 2022Article
- Disease criteria of systemic lupus erythematosus (SLE); the potential role of non-criteria autoantibodies.Journal of translational autoimmunity · 2022Article
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Authors and funding
42 authors at 20 institutions in 12 countries.
Funding
Abstract
objectiveThe spectrum of antinuclear antibodies (ANAs) is changing to include both nuclear staining as well as cytoplasmic and mitotic cell patterns (CMPs) and accordingly a change is occurring in terminology to anticellular antibodies. This study examined the prevalence of indirect immunofluorescence (IIF) anticellular antibody staining using the Systemic Lupus International Collaborating Clinics inception cohort.
methodsAnticellular antibodies were detected by IIF on HEp-2000 substrate using the baseline serum. Three serologic subsets were examined: ANA positive (presence of either nuclear or mixed nuclear/CMP staining), anticellular antibody negative (absence of any intracellular staining), and isolated CMP staining. The odds of being anticellular antibody negative versus ANA or isolated CMP positive was assessed by multivariable analysis.
resultsA total of 1,137 patients were included; 1,049 (92.3%) were ANA positive, 71 (6.2%) were anticellular antibody negative, and 17 (1.5%) had an isolated CMP. The isolated CMP-positive group did not differ from the ANA-positive or anticellular antibody-negative groups in clinical, demographic, or serologic features. Patients who were older (odds ratio [OR] 1.02 [95% confidence interval (95% CI) 1.00, 1.04]), of white race/ethnicity (OR 3.53 [95% CI 1.77, 7.03]), or receiving high-dose glucocorticoids at or prior to enrollment (OR 2.39 [95% CI 1.39, 4.12]) were more likely to be anticellular antibody negative. Patients on immunosuppressants (OR 0.35 [95% CI 0.19, 0.64]) or with anti-SSA/Ro 60 (OR 0.41 [95% CI 0.23, 0.74]) or anti-U1 RNP (OR 0.43 [95% CI 0.20, 0.93]) were less likely to be anticellular antibody negative.
conclusionIn newly diagnosed systemic lupus erythematosus, 6.2% of patients were anticellular antibody negative, and 1.5% had an isolated CMP. The prevalence of anticellular antibody-negative systemic lupus erythematosus will likely decrease as emerging nomenclature guidelines recommend that non-nuclear patterns should also be reported as a positive ANA.
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