Evidence map›Paper›PMID 30044455›Full record

ArticleInternational journal of molecular sciences2018

A Hydroxypyrone-Based Inhibitor of Metalloproteinase-12 Displays Neuroprotective Properties in Both

Jonathan Vinet, Anna-Maria Costa, Manuel Salinas-Navarro, Giuseppina Leo, Lieve Moons, Lutgarde Arckens, Giuseppe Biagini

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Pathophysiology of Status Epilepticus Revisited.International journal of molecular sciences · 2025
    Review
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  7. A Proline Derivative-Enriched Fraction fromInternational journal of molecular sciences · 2020
    Article
  8. Article
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  11. Article
  12. The Vessels Shaping Mental Health or Illness.The open neurology journal · 2019
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jonathan VinetLaboratory of Experimental Epileptology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. jonathan.vinet@unimore.it.
Anna-Maria CostaLaboratory of Experimental Epileptology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. annamaria.costa@unimore.it.ORCID 0000-0003-3152-9890
Manuel Salinas-NavarroLaboratory of Neural Circuit Development and Regeneration, Department of Biology, KU Leuven, 3000 Leuven, Belgium. manuel.salinas@um.es.
Giuseppina LeoLaboratory of Experimental Epileptology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. giuseppina.leo@unimore.it.
Lieve MoonsLaboratory of Neural Circuit Development and Regeneration, Department of Biology, KU Leuven, 3000 Leuven, Belgium. lieve.moons@kuleuven.be.
Lutgarde ArckensLaboratory of Neuroplasticity and Neuroproteomics, Department of Biology, KU Leuven, 3000 Leuven, Belgium. lut.arckens@kuleuven.be.
Giuseppe BiaginiLaboratory of Experimental Epileptology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. giuseppe.biagini@unimore.it.
University of Modena and Reggio Emilia · ITKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, we showed that matrix metalloproteinase-12 (MMP-12) is highly expressed in microglia and myeloid infiltrates, which are presumably involved in blood⁻brain barrier (BBB) leakage and subsequent neuronal cell death that follows

Indexed as

AnimalsCA3 Region, HippocampalDentate GyrusDisease Models, AnimalEnzyme InhibitorsHumansMaleMatrix Metalloproteinase 12Mice, Inbred C57BLNerve CrushNeuroprotective AgentsOptic NerveOptic Nerve InjuriesPilocarpinePyronesRatsEnzyme Inhibitorsmatrix metallopeptidase 12, ratMatrix Metalloproteinase 12Neuroprotective AgentsPilocarpinePyronesblood–brain barrier leakagemetalloproteinase-12optical neuropathypilocarpineretinal ganglion cellsstatus epilepticus

Identifiers

PMID30044455
PMCPMC6121268
OpenAlexW2884963024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.