Evidence map›Paper›PMID 30044398›Full record

Trial reportNutrients2018

A Synergistic Formulation of Plant Extracts Decreases Postprandial Glucose and Insulin Peaks: Results from Two Randomized, Controlled, Cross-Over Studies Using Real-World Meals.

Edyta Adamska-Patruno, Katarzyna Billing-Marczak, Marek Orlowski, Maria Gorska, Marcin Krotkiewski, Adam Kretowski

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Guava (Nutrients · 2019
    Trial
  2. Effect of Thai Herbal Remedy NL Inhibits Lipid Accumulation on 3T3-L1 Adipocyte Cells.Advances in pharmacological and pharmaceutical sciences · 2024
    Article
  3. A comprehensiveFrontiers in pharmacology · 2024
    Review
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Edyta Adamska-PatrunoClinical Research Centre, Medical University of Bialystok, M.C. Sklodowskiej 24A, 15-276 Bialystok, Poland. edyta.adamska@wp.pl.ORCID 0000-0002-8805-0744
Katarzyna Billing-MarczakMarmar Investments Sp. z o.o., Slominskiego 15, lok 509, 00-195 Warsaw, Poland. kmarczak@marmarinvestment.pl.ORCID 0000-0003-0343-1765
Marek OrlowskiMarmar Investments Sp. z o.o., Slominskiego 15, lok 509, 00-195 Warsaw, Poland. morlowski@adiuvoinvestments.com.
Maria GorskaDepartment of Endocrinology, Diabetology, and Internal Medicine, Medical University of Bialystok, M.C. Sklodowskiej 24A, 15-276 Bialystok, Poland. mgorska25@wp.pl.
Marcin KrotkiewskiMarmar Investments Sp. z o.o., Slominskiego 15, lok 509, 00-195 Warsaw, Poland.
Adam KretowskiClinical Research Centre, Medical University of Bialystok, M.C. Sklodowskiej 24A, 15-276 Bialystok, Poland. adamkretowski@wp.pl.
Medical University of Białystok · PLUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the efficacy of a plant-derived dietary supplement with respect to decreasing postprandial glucose and insulin peaks after the intake of real-world meals. Two randomized, double-blind, placebo-controlled, cross-over experiments were conducted on healthy subjects who received a supplement containing extracts of white mulberry, white bean, and green coffee or one containing the three extracts with added fibre before consuming high-GI/GL (glycaemic index/glycaemic load) meals. In study one, 32 subjects received an investigational product/placebo before a standardized meal at two visits. In study two, 150 subjects received an investigational product/placebo before five different standardized meals. Postprandial glucose and insulin concentrations were lower 20⁻35 min after meal intake among subjects taking the investigational product, and fewer episodes of postprandial reactive hypoglycaemia were noted. For example, after consuming breakfast cereal with milk, lower glucose peaks were observed for the investigational product (vs. placebo) after 20 min (100.2 ± 1.97 vs. 112.5 ± 3.12 mg/dL, respectively;

Indexed as

Blood GlucoseMealsPostprandial PeriodAdolescentAdultCross-Over StudiesDouble-Blind MethodFemaleHumansInsulinMaleMiddle AgedPlant ExtractsYoung AdultBlood GlucoseInsulinPlant Extractsmetabolic syndromenatural productobesityoverweightplant extractspostprandial glucose peakspostprandial insulin peakspre-diabetestype 2 diabetes

Identifiers

PMID30044398
PMCPMC6115802
OpenAlexW2883717692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.