ArticleEnvironmental health perspectives2018
A Suspect Screening Method for Characterizing Multiple Chemical Exposures among a Demographically Diverse Population of Pregnant Women in San Francisco.
Article in Environmental health perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 69 citations in OpenAlex.
- Unraveling Plastic-Related Chemical Exposures during Pregnancy and Their Associations with Pregnancy Outcomes Using Suspect Screening Analysis.Environment & health (Washington, D.C.) · 2026Article
- Prenatal melamine, aromatic amine, and psychosocial stress exposures and their association with gestational diabetes mellitus in a San Francisco pregnancy cohort.Journal of exposure science & environmental epidemiology · 2025Article
- Metabolome informs about the chemical exposome and links to brain health.Environment international · 2025Review
- High-Throughput Solid Phase Extraction for Targeted and Nontargeted Exposomics.Analytical chemistry · 2025Article
- Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort.Environment international · 2025Article
- Rapid identification of reproductive toxicants among environmental chemicals using an in vivo evaluation of gametogenesis in budding yeast Saccharomyces cerevisiae.Reproductive toxicology (Elmsford, N.Y.) · 2024Article
- Screening and characterization of 133 physiologically-relevant environmental chemicals for reproductive toxicity.Reproductive toxicology (Elmsford, N.Y.) · 2024Article
- Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs).Exposome · 2024Article
- Investigating geographic differences in environmental chemical exposures in maternal and cord sera using non-targeted screening and silicone wristbands in California.Journal of exposure science & environmental epidemiology · 2023Article
- Extending Nontargeted Discovery of Environmental Chemical Exposures during Pregnancy and Their Association with Pregnancy Complications-A Cross-Sectional Study.Environmental health perspectives · 2023Article
- 2,4-di-tert-butylphenol exposure impairs osteogenic differentiation.Toxicology and applied pharmacology · 2023Article
- Evaluation of a rapid, generic human gestational dose model.Reproductive toxicology (Elmsford, N.Y.) · 2022Article
- Article
- A Deep Dive into the Complex Chemical Mixture and Toxicity of Tire Wear Particle Leachate in Fathead Minnow.Environmental toxicology and chemistry · 2022Article
- Associations between the Maternal Exposome and Metabolome during Pregnancy.Environmental health perspectives · 2022Article
- Metabolomics and the Multi-Omics View of Cancer.Metabolites · 2022Review
- Large-Scale Implementation and Flaw Investigation of Human Serum Suspect Screening Analysis for Industrial Chemicals.Journal of the American Society for Mass Spectrometry · 2021Article
- A Comprehensive Non-targeted Analysis Study of the Prenatal Exposome.Environmental science & technology · 2021Article
- Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery.Environmental health perspectives · 2021Article
- Suspect Screening, Prioritization, and Confirmation of Environmental Chemicals in Maternal-Newborn Pairs from San Francisco.Environmental science & technology · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
background
objectivesWe aimed to profile exposure to multiple environmental organic acids (EOAs) and identify novel chemicals that have not been previously biomonitored in a diverse population of pregnant women.
methodsWe used liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF/MS) to perform a suspect screen for 696 EOAs, (e.g., phenols and phthalate metabolites) on the maternal serum collected at delivery from 75 pregnant women delivering at two large San Francisco Hospitals. We examined demographic differences in peak areas and detection frequency (DF) of suspect EOAs using a Kruskal-Wallis Rank Sum test or Fisher's exact test. We confirmed selected suspects by comparison with their respective reference standards.
resultsWe detected, on average, 56 [standard deviation (SD)]: 8) suspect EOAs in each sample (range: 32-73). Twelve suspect EOAs with DF≥60 were matched to 21 candidate compounds in our EOA database, two-thirds of which are novel chemicals. We found demographic differences in DF for 13 suspect EOAs and confirmed the presence of 6 priority novel chemicals: 2,4-Di-tert-butylphenol, Pyrocatechol, 2,4-Dinitrophenol, 3,5-Di-tert-butylsalicylic acid, 4-Hydroxycoumarin, and 2'-Hydroxyacetophenone (or 3'-Hydroxyacetophenone). The first two are high-production-volume chemicals in the United States.
conclusionSuspect screening in human biomonitoring provides a viable method to characterize a broad spectrum of environmental chemicals to prioritize for targeted method development and quantification. https://doi.org/10.1289/EHP2920.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.