Evidence map›Paper›PMID 30044221›Full record

ArticleeLife2018

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABA

Swastik Phulera, Hongtao Zhu, Jie Yu, Derek P Claxton, Nate Yoder, Craig Yoshioka, Eric Gouaux

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 161 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Molecular assemblies and pharmacology of cerebellar GABAProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. GABAMolecular cell · 2025
    Article
  12. Review
  13. Article
  14. Modular Structure and Polymerization Status of GABAInternational journal of molecular sciences · 2024
    Article
  15. Review
  16. Article
  17. Phenols and GABAFrontiers in pharmacology · 2024
    Review
  18. Epileptic EncephalopathyBiomolecules · 2023
    Article
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Swastik Phulera *Vollum Institute, Oregon Health and Science University, Portland, United States.ORCID http://orcid.org/0000-0002-1272-7712
Hongtao Zhu *Vollum Institute, Oregon Health and Science University, Portland, United States.ORCID http://orcid.org/0000-0003-1522-0500
Jie Yu *Vollum Institute, Oregon Health and Science University, Portland, United States.
Derek P ClaxtonVollum Institute, Oregon Health and Science University, Portland, United States.ORCID http://orcid.org/0000-0002-1374-7176
Nate YoderVollum Institute, Oregon Health and Science University, Portland, United States.ORCID http://orcid.org/0000-0002-9017-0673
Craig YoshiokaVollum Institute, Oregon Health and Science University, Portland, United States.
Eric GouauxVollum Institute, Oregon Health and Science University, Portland, United States.ORCID http://orcid.org/0000-0002-8549-2360
Oregon Health & Science University · USHoward Hughes Medical Institute · US

Funding

Structural biology of neurotransmitter ion channelsR01GM100400 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI GOUAUX, JAMES E · 2012 to 2020
$2.3M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM100400
6 · The paper itself

Abstract

Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABA

Indexed as

AnimalsBenzodiazepinesBinding Sitesgamma-Aminobutyric AcidHumansNervous SystemProtein MultimerizationProtein SubunitsRatsReceptors, GABA-AStructure-Activity RelationshipSynaptic TransmissionBenzodiazepinesgamma-Aminobutyric AcidProtein SubunitsReceptors, GABA-Acryo-electron microscopyCys loop receptorsGABAGABA receptorsion channelmolecular biophysicsneuroscienceneurotransmissionratstructural biology

Identifiers

PMID30044221
PMCPMC6086659
OpenAlexW2883936328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.