ArticleThe British journal of radiology2018
Model-based cardiac dose estimation in radiation treatment of left breast cancer.
Article in The British journal of radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Correlations between patient-specific parameters and dosimetric indices for personalized breast cancer radiotherapy.Scientific reports · 2024Article
- Development of deep learning chest X-ray model for cardiac dose prediction in left-sided breast cancer radiotherapy.Scientific reports · 2022Article
- Preoperative spirometry and BMI in deep inspiration breath-hold radiotherapy: the early detection of cardiac and lung dose predictors without radiation exposure.Radiation oncology (London, England) · 2022Article
- Dosimetric comparison between different tangential field arrangements during left-sided breast cancer radiotherapy.Radiological physics and technology · 2021Article
- Detection of Intrafractional Set-Up Errors Using Electronic Portal Imaging Device-basedJournal of medical physicsArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objective: To develop a mathematical model for cardiac dose estimation for patients who have been treated for left-sided breast cancer without CT data.
methods: After obtaining institutional review board approvals, 147 patients with left-sided breast cancer were selected that were treated supine with opposed tangents. The heart blocks from the tangential fields were removed and dose calculations were performed with 6 MV beams using an advanced algorithm. This study was performed with CT data with DRR to represent a radiographic simulator image of yesteryear treatments. The beam's eye-view images showing delineated breast, lung and heart were created to represent views on radiograph. The maximum heart distance (MHD) was recorded and irradiated heart area (AREA) was computed by combination of triangles and rectangles. Based on accurate 3D dose calculation, mean dose (D
results: The treatment parameters calculated by MHD and segments using 2D radiographs were within 2% of the actual dosimetric parameters computed from the 3D planning system. The MHD and AREA vs D
conclusion: The proposed mathematical model for the cardiac dose estimation is accurate within ±3% using a radiograph without CT data. This provides avenues for patient pooling in future studies related to radiation dose and cardiac toxicity. These results will help in estimating cardiac dose analysis accurately from previous studies as well as in centers still using 2D planning. ADVANCES IN KNOWLEDGE:: The evidence of cardiac risk following radiotherapy continues to be one of the important considerations for the management of left-sided breast cancer patients. One of the problem in the estimation of dose-risk effects is the reconstruction of heart dose for pre-CT treatments. In this study, a simple mathematical model is presented that could estimate cardiac dose within ±3% in left breast cancer treatment from 2D radiograph where CT data do not exist.
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