ArticleCell metabolism2018
Time-Dependent Molecular Responses Differ between Gastric Bypass and Dieting but Are Conserved Across Species.
Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed.
- Remodeling of Oncogene-Related Molecular Networks Following Bariatric Surgery: a Multi-Omics Study.Obesity surgery · 2026Article
- Intestinal HIF1α is dispensable for bariatric surgery-mediated metabolic benefits but protects against diet-induced obesity and hepatic steatosis.International journal of obesity (2005) · 2026Article
- Influence of Biological Sex on Metabolic and Adipokine Responses after Metabolic-Bariatric Surgery: A Narrative Review.Current obesity reports · 2026Review
- Gut microbiota alterations induced by Roux-en-Y gastric bypass result in glucose-lowering by enhancing intestinal glucose excretion.Gut microbes · 2025Article
- Roux-en-Y gastric bypass surgery decreases intestinal aryl hydrocarbon receptor signaling in male mice.Physiological reports · 2025Article
- The role of the gut-brain axis in bariatric surgery.Current opinion in neurobiology · 2025Review
- Intraduodenal administration of Reg3g improves gut barrier function and mitigates hepatic steatosis in mice.American journal of physiology. Endocrinology and metabolism · 2025Article
- Sleeve gastrectomy reveals the plasticity of the human gastric epithelium.Nature communications · 2025Article
- Thiamine, gastrointestinal beriberi and acetylcholine signaling.Frontiers in nutrition · 2025Review
- Single-cell resolution of intestinal regeneration in pythons without crypts illuminates conserved vertebrate regenerative mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Postprandial metabolomics analysis reveals disordered serotonin metabolism in post-bariatric hypoglycemia.The Journal of clinical investigation · 2024Article
- Inhibition of somatostatin enhances the long-term metabolic outcomes of sleeve gastrectomy in mice.Molecular metabolism · 2024Article
- RNA sequencing unravels novel L cell constituents and mechanisms of GLP-1 secretion in human gastric bypass-operated intestine.Diabetologia · 2024Article
- Short-Term Metabolic Changes and Their Physiological Mediators in the Roux-en-Y Gastric Bypass Bariatric Surgery.Obesity surgery · 2024Article
- Hepatic lipid-associated macrophages mediate the beneficial effects of bariatric surgery against MASH.Research square · 2023Article
- Intestinal Pgc1α ablation protects from liver steatosis and fibrosis.JHEP reports : innovation in hepatology · 2023Article
- Impact of intestinal microenvironments in obesity and bariatric surgery on shaping macrophages.Immunometabolism (Cobham, Surrey) · 2023Review
- The DECON pilot project investigates predictive markers for successful bariatric surgery.Scientific reports · 2023Article
- Glucose metabolism after bariatric surgery: implications for T2DM remission and hypoglycaemia.Nature reviews. Endocrinology · 2023Review
- Regulation of body weight: Lessons learned from bariatric surgery.Molecular metabolism · 2023Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
The effectiveness of Roux-en-Y gastric bypass (RYGB) against obesity and its comorbidities has generated excitement about developing new, less invasive treatments that use the same molecular mechanisms. Although controversial, RYGB-induced improvement of metabolic function may not depend entirely upon weight loss. To elucidate the differences between RYGB and dieting, we studied several individual organ molecular responses and generated an integrative, interorgan view of organismal physiology. We also compared murine and human molecular signatures. We show that, although dieting and RYGB can bring about the same degree of weight loss, post-RYGB physiology is very different. RYGB induces distinct, organ-specific adaptations in a temporal pattern that is characterized by energetically demanding processes, which may be coordinated by HIF1a activation and the systemic repression of growth hormone receptor signaling. Many of these responses are conserved in rodents and humans and may contribute to the remarkable ability of surgery to induce and sustain metabolic improvement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.