ArticleCell metabolism2018
Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation.
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Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 260 papers.
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260citing papers in PubMed
16.4field-weighted citation impact, top 1% of its field
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260 citing papers in PubMed, 368 citations in OpenAlex.
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- Improving Immune Checkpoint Therapy in the Tumor Microenvironment by Targeting T Cell Metabolism.Endocrine, metabolic & immune disorders drug targets · 2026Review
- Metabolic checkpoints in the regulation of Th17 cells: implications for uveitis pathogenesis and therapy.Frontiers in immunology · 2026Review
- Regulating the regulators via targeting CD38 in the tumor microenvironment.Frontiers in immunology · 2026Review
200 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors at 7 institutions in 3 countries.
Brenda RaudInstitute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Niedersachsen 30625, Germany.
Dominic G RoyGoodman Cancer Research Centre, Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada.
Ajit S DivakaruniDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Tatyana N TarasenkoMetabolism, Infection, and Immunity Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Raimo FrankeDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Eric H MaGoodman Cancer Research Centre, Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada.
Bozena SamborskaGoodman Cancer Research Centre, Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada.
Wei Yuan HsiehDepartment of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Alison H WongGoodman Cancer Research Centre, Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada.
Philipp StüveInstitute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Niedersachsen 30625, Germany.
Catharina Arnold-SchraufInstitute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Niedersachsen 30625, Germany.
Melanie GuderianInstitute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Niedersachsen 30625, Germany.
Matthias LochnerInstitute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Niedersachsen 30625, Germany.
Shakuntala RampertaapDepartment of Laboratory Medicine, National Institutes of Health, Bethesda, MD 20892, USA.
Kimberly RomitoDepartment of Laboratory Medicine, National Institutes of Health, Bethesda, MD 20892, USA.
Joseph MonsaleDepartment of Laboratory Medicine, National Institutes of Health, Bethesda, MD 20892, USA.
Mark BrönstrupDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Steven J BensingerDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Anne N MurphyDepartment of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Peter J McGuireMetabolism, Infection, and Immunity Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Russell G JonesGoodman Cancer Research Centre, Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada. Electronic address: russell.jones@mcgill.ca.
Tim SparwasserInstitute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Niedersachsen 30625, Germany. Electronic address: sparwasser.tim@mh-hannover.de.
Luciana BerodInstitute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Niedersachsen 30625, Germany. Electronic address: luciana.berod@twincore.de.
Helmholtz Centre for Infection Research · DEMcGill University Health Centre · CANational Institutes of Health · USUniversity of California, Los Angeles · USCenter for Experimental and Clinical Infection Research · DENational Human Genome Research Institute · USUniversity of California, San Diego · US
Funding
Metabolism, infection and immunity in inborn errors of mitochondrial metabolismZIAHG200381 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI MCGUIRE, PETER · 2012 to 2025
$21.7MUnderstanding the Influence of Lipid Homeostasis on T cell FunctionP01HL146358 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FONG, LOREN GI · 2019 to 2023
$11.7MTargeting the mitochondrial pyruvate carrier to treat neurodegenerative diseaseR01NS087611 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, GEOFFREY A, MURPHY, ANNE N. · 2014 to 2018
$2.9MCIHR MOP-142259Intramural NIH HHS ZIA HG200381NHLBI NIH HHS P01 HL146358NINDS NIH HHS R01 NS087611
Abstract
T cell subsets including effector (T
Indexed as
Acetyl-CoA CarboxylaseAnimalsCarnitine O-PalmitoyltransferaseCD8-Positive T-LymphocytesCell DifferentiationCells, CulturedChildChild, PreschoolEpoxy CompoundsFatty AcidsFemaleGene Knockout TechniquesHumansImmunologic MemoryLymphocyte ActivationMaleAcacb protein, mouseAcetyl-CoA CarboxylaseCarnitine O-PalmitoyltransferaseCPT1B protein, mouseEpoxy CompoundsetomoxirFatty Acidsacetyl-CoA carboxylaseAMPKcarnitine palmitoyltransferaseCD8 T cellsCPTetomoxirfatty acid oxidationmemory T cellsregulatory T cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.