Evidence map›Paper›PMID 30043752›Full record

ArticleCell metabolism2018

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis.

Ajit S Divakaruni, Wei Yuan Hsieh, Lucía Minarrieta, Tin N Duong, Kristen K O Kim, Brandon R Desousa, Alexander Y Andreyev, Caitlyn E Bowman, Kacey Caradonna, Brian P Dranka and 11 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 211 papers.

0numbers the graph read from it
0cells of the map it votes in
211citing papers in PubMed
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

211 citing papers in PubMed, 348 citations in OpenAlex.

  1. Trial
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  4. Article
  5. miR-146a mimic therapy protects against platelet-mediated thrombosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
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  8. Innate immunity: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
    Review
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151 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 2 countries.

Ajit S DivakaruniDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: adivakaruni@mednet.ucla.edu.
Wei Yuan HsiehDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Lucía MinarrietaInstitute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture Between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.
Tin N DuongDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Kristen K O KimDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Brandon R DesousaDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Alexander Y AndreyevDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
Caitlyn E BowmanDepartment of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kacey CaradonnaAgilent Technologies, 5301 Stevens Creek Boulevard, Santa Clara, CA 95051, USA.
Brian P DrankaAgilent Technologies, 5301 Stevens Creek Boulevard, Santa Clara, CA 95051, USA.
David A FerrickAgilent Technologies, 5301 Stevens Creek Boulevard, Santa Clara, CA 95051, USA.
Marc LiesaDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Linsey StilesDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
George W RogersAgilent Technologies, 5301 Stevens Creek Boulevard, Santa Clara, CA 95051, USA.
Daniel BraasDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA Metabolomics Center and Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Theodore P CiaraldiVeterans Affairs San Diego Healthcare System, La Jolla, CA 92161, USA; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Michael J WolfgangDepartment of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Tim SparwasserInstitute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture Between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.
Luciana BerodInstitute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture Between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.
Steven J BensingerDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Anne N MurphyDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
University of California, Los Angeles · USAgilent Technologies (United States) · USUniversity of California, San Diego · USCenter for Experimental and Clinical Infection Research · DEJohns Hopkins University · USHelmholtz Centre for Infection Research · DE

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Linda M Liau · 2017 to 2026
$25.2M
BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Understanding the Influence of Lipid Homeostasis on T cell FunctionP01HL146358 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FONG, LOREN GI · 2019 to 2023
$11.7M
Regulation of Neuronal Lipid Homeostasis By ThioesterasesR01NS072241 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WOLFGANG, MICHAEL J. · 2011 to 2020
$4.0M
Targeting the mitochondrial pyruvate carrier to treat neurodegenerative diseaseR01NS087611 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, GEOFFREY A, MURPHY, ANNE N. · 2014 to 2018
$2.9M
Understanding the influence of SREBP signaling on CD4 T helper cell biologyR01AI122282 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BENSINGER, STEVEN J · 2016 to 2020
$1.9M
NCI NIH HHS P50 CA211015NHLBI NIH HHS P01 HL146358NIAID NIH HHS R01 AI122282NIGMS NIH HHS T32 GM007445NINDS NIH HHS R01 NS072241NINDS NIH HHS R01 NS087611
6 · The paper itself

Abstract

Long-chain fatty acid (LCFA) oxidation has been shown to play an important role in interleukin-4 (IL-4)-mediated macrophage polarization (M(IL-4)). However, many of these conclusions are based on the inhibition of carnitine palmitoyltransferase-1 with high concentrations of etomoxir that far exceed what is required to inhibit enzyme activity (EC

Indexed as

MacrophagesMitochondria3T3 CellsA549 CellsAcyl Coenzyme AAnimalsCarnitine O-PalmitoyltransferaseEnzyme InhibitorsEpoxy CompoundsFatty AcidsHCT116 CellsHep G2 CellsHomeostasisHumansInterleukin-4LiverAcyl Coenzyme ACarnitine O-PalmitoyltransferaseCPT1B protein, mouseEnzyme InhibitorsEpoxy Compoundsetomoxiretomoxiryl-coenzyme AFatty AcidsInterleukin-4Mitochondrial ADP, ATP Translocasescoenzyme ACPT-1CPT-2interleukin 4long-chain fatty acid oxidationmacrophage polarizationmitochondriaoxidative phosphorylationpantothenate

Identifiers

PMID30043752
PMCPMC6125190
OpenAlexW2810749981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.