Evidence map›Paper›PMID 30043637›Full record

Trial reportBiomarkers in medicine2018

Inflammatory biomarker in adipose stem cells of women with endometrial cancer.

Faina Linkov, Sharon L Goughnour, Shalkar Adambekov, Anna Lokshin, Joseph L Kelley, Paniti Sukumvanich, John T Comerci, Kacey G Marra, Lauren E Kokai, J Peter Rubin and 3 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Biomarkers in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Faina LinkovDepartment of Obstetrics, Gynecology, & Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, 3380 Blvd of the Allies, Pittsburgh, PA 15213, USA.
Sharon L GoughnourDepartment of Obstetrics, Gynecology, & Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, 3380 Blvd of the Allies, Pittsburgh, PA 15213, USA.
Shalkar AdambekovDepartment of Epidemiology, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA 15216, USA.
Anna LokshinDepartment of Medicine, UPMC Cancer Pavilion, 5150 Centre Avenue, Pittsburgh, PA 15232, USA.
Joseph L KelleyDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Hospital, 300 Halket Street, Pittsburgh, PA 15213, USA.
Paniti SukumvanichDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Hospital, 300 Halket Street, Pittsburgh, PA 15213, USA.
John T ComerciDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Hospital, 300 Halket Street, Pittsburgh, PA 15213, USA.
Kacey G MarraDepartment of Plastic Surgery, University of Pittsburgh School of Medicine, 3550 Terrace Street, Scaife Hall, Pittsburgh, PA 15261, USA.
Lauren E KokaiDepartment of Plastic Surgery, University of Pittsburgh School of Medicine, 3550 Terrace Street, Scaife Hall, Pittsburgh, PA 15261, USA.
J Peter RubinDepartment of Plastic Surgery, University of Pittsburgh School of Medicine, 3550 Terrace Street, Scaife Hall, Pittsburgh, PA 15261, USA.
Anda M VladDepartment of Obstetrics, Gynecology, & Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, 3380 Blvd of the Allies, Pittsburgh, PA 15213, USA.
Brian J PhilipsDepartment of Obstetrics, Gynecology, & Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, 3380 Blvd of the Allies, Pittsburgh, PA 15213, USA.
Robert P EdwardsDepartment of Obstetrics, Gynecology, & Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, 3380 Blvd of the Allies, Pittsburgh, PA 15213, USA.
University of Pittsburgh · USMagee-Womens Hospital · USMagee-Womens Research Institute · USUPMC Hillman Cancer Center · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Urine and Serum Biomarkers for Screening and Diagnosis of Ovarian CancerR01CA108990 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOKSHIN, ANNA E. · 2005 to 2014
$5.3M
Validation of pancreatic cancer biomarkers in large prospective cohortsR01CA196286 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOKSHIN, ANNA E. · 2015 to 2017
$1.4M
Identification of Early Markers for Ovarian CancerR01CA098642 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOKSHIN, ANNA E. · 2003 to 2006
$1.3M
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA098642NCI NIH HHS R01 CA108990NCI NIH HHS R01 CA196286
6 · The paper itself

Abstract

aimTo explore inflammatory biomarkers secreted by adipose stem cells (ASCs) in omental, retroperitoneal and subcutaneous adipose tissues of women with endometrial cancer. PATIENTS &

methodsASCs were collected from 22 women, aged 35-83 years, undergoing hysterectomy for endometrial cancer. Angiopoietin-2, EGF, IL-8, leptin, VEGFA, VEGFC and VEFGD levels in the ASC-conditioned media were analyzed by Luminex.

resultsWe found a significant difference between the three depots for IL-8 (p < 0.0001), with the highest levels of IL-8 in the omental depot. VEGFA levels were highest in the retroperitoneal depot.

conclusionThis is one of the first studies to explore biomarker expression in ASC-conditioned media in adipose tissue. ASC characteristics may be important to evaluate in relation to cancer risk.

Indexed as

Gene Expression Regulation, NeoplasticAdultAgedAged, 80 and overBiomarkers, TumorCytokinesEndometrial NeoplasmsFemaleHumansMiddle AgedNeoplasm ProteinsStem CellsSubcutaneous FatBiomarkers, TumorCytokinesNeoplasm Proteinsadipogenenesisadipose derived stem cellsadipose tissuebiomarkersendometrial cancerIL-8inflammationmetabolic diseaseobesityprevention

Identifiers

PMID30043637
PMCPMC6439519
OpenAlexW2884163544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.