Evidence map›Paper›PMID 30043625›Full record

ReviewAmerican journal of physiology. Renal physiology2018

Single-molecule labeling for studying trafficking of renal transporters.

Ankita Bachhawat Jaykumar, Paulo S Caceres, Pablo A Ortiz

Open access · bronzeAbstract readReview
In one paragraph

Review in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Recent advances in renal epithelial transport.American journal of physiology. Renal physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ankita Bachhawat JaykumarHypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital , Detroit, Michigan.
Paulo S CaceresHypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital , Detroit, Michigan.
Pablo A OrtizHypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital , Detroit, Michigan.
Wayne State University · USHenry Ford Hospital · US

Funding

Tubuloglomerular Feedback Regulation by Carbon MonoxideP01HL090550 · NHLBI · HENRY FORD HEALTH SYSTEM · PI ORTIZ, PABLO A. · 2009 to 2013
$10.2M
Fructose induced salt-sensitive hypertension: Role of thick ascending limb transportR01DK107263 · NIDDK · HENRY FORD HEALTH SYSTEM · PI ORTIZ, PABLO A. · 2016 to 2020
$2.1M
NHLBI NIH HHS P01 HL090550NIDDK NIH HHS R01 DK107263
6 · The paper itself

Abstract

The ability to detect and track single molecules presents the advantage of visualizing the complex behavior of transmembrane proteins with a time and space resolution that would otherwise be lost with traditional labeling and biochemical techniques. Development of new imaging probes has provided a robust method to study their trafficking and surface dynamics. This mini-review focuses on the current technology available for single-molecule labeling of transmembrane proteins, their advantages, and limitations. We also discuss the application of these techniques to the study of renal transporter trafficking in light of recent research.

Indexed as

Microscopy, FluorescenceAnimalsExpressed Sequence TagsHumansKidneyLuminescent ProteinsMembrane Transport ProteinsProtein TransportRecombinant ProteinsSingle-Domain AntibodiesSingle Molecule ImagingLuminescent ProteinsMembrane Transport ProteinsRecombinant ProteinsSingle-Domain Antibodiesprotein/peptide tagssingle molecule labelingtrafficking

Identifiers

PMID30043625
PMCPMC6293308
OpenAlexW2884176916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.