ArticleHuman brain mapping2018
Neuromodulation of reinforced skill learning reveals the causal function of prefrontal cortex.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Dissociable Causal Roles of Dorsolateral Prefrontal Cortex and Primary Motor Cortex over the Course of Motor Skill Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Prefrontal stimulation prior to motor sequence learning alters multivoxel patterns in the striatum and the hippocampus.Scientific reports · 2021Article
- Hippocampal and striatal responses during motor learning are modulated by prefrontal cortex stimulation.NeuroImage · 2021Article
- Reward boosts reinforcement-based motor learning.iScience · 2021Article
- Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Explaining Individual Differences in Motor Behavior by Intrinsic Functional Connectivity and Corticospinal Excitability.Frontiers in neuroscience · 2020Article
- Neuromodulation of reinforced skill learning reveals the causal function of prefrontal cortex.Human brain mapping · 2018Article
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Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence has suggested functional interactions between prefrontal cortex (PFC) and dissociable large-scale networks. However, how these networks interact in the human brain to enable complex behaviors is not well-understood. Here, using a combination of behavioral, brain stimulation and neuroimaging paradigms, we tested the hypothesis that human PFC is required for successful reinforced skill formation. We additionally tested the extent to which PFC-dependent skill formation is related to intrinsic functional communication with this region. We report that inhibitory noninvasive transcranial magnetic stimulation over lateral PFC, a hub region with a diverse connectivity profile, causally modulated effective reinforcement-based motor skill acquisition. Furthermore, PFC-dependent skill formation was strongly related to the strength of functional connectivity between the PFC and regions in the sensorimotor network. These results point to the involvement of lateral PFC in the neural architecture that underlies the acquisition of complex skills, and suggest that, in relation to skill acquisition, this region may be involved in functional interactions with sensorimotor networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.