Evidence map›Paper›PMID 30043447›Full record

ArticleDevelopmental psychobiology2019

Impact of pubertal timing and depression on error-related brain activity in anxious youth.

Amy T Peters, Katie L Burkhouse, Autumn Kujawa, Kaveh Afshar, Kate D Fitzgerald, Christopher S Monk, Greg Hajcak, K Luan Phan

Abstract read
In one paragraph

Article in Developmental psychobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Amy T PetersDepartment of Psychiatry, University of Illinois at Chicago, Chicago, Illinois.ORCID 0000-0003-0224-647X
Katie L BurkhouseDepartment of Psychiatry, University of Illinois at Chicago, Chicago, Illinois.
Autumn KujawaDepartment of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee.
Kaveh AfsharDepartment of Psychiatry, University of Illinois at Chicago, Chicago, Illinois.
Kate D FitzgeraldDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Christopher S MonkDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Greg HajcakDepartment of Psychology and Biomedical Sciences, Florida State University, Tallahassee, Florida.
K Luan PhanDepartment of Psychiatry, University of Illinois at Chicago, Chicago, Illinois.
University of Illinois Chicago · USUniversity of Michigan · USFlorida State University · USVanderbilt University · US

Funding

Brain Markers of Anxiety Disorders and SSRI Treatment in Children and AdolescentsR01MH086517 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MONK, CHRISTOPHER STEPHEN, PHAN, K. LUAN · 2010 to 2014
$2.8M
Brain-Behavior Markers of Emotion in Depressed Mothers and Their DaughtersK23MH113793 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BURKHOUSE, KATIE L · 2017 to 2021
$1.0M
Neurodevelopmental Perspective on Inflammation, Loss, and NeurocognitionF31MH108258 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PETERS, AMY · 2015 to 2017
$105k
NIMH NIH HHS F31 MH108258NIMH NIH HHS F31- MH108258-03NIMH NIH HHS K23 MH113793NIMH NIH HHS K23-MH113793-01NIMH NIH HHS R01 MH086517
6 · The paper itself

Abstract

Anxiety disorders are associated with enhanced error-related negativity (ERN) across development but it remains unclear whether alterations in brain electrophysiology are linked to the timing of puberty. Pubertal timing and alterations of prefrontal and limbic development are implicated in risk for depression, but the interplay of these factors on the ERN-anxiety association has not been assessed. We examined the unique and interactive effects of pubertal timing and depression on the ERN in a sample of youth 10-19 years old with anxiety disorders (n = 30) or no history of psychopathology (n = 30). Earlier pubertal maturation was associated with an enhanced ERN. Among early, but not late maturing youth, higher depressive symptoms were associated with a reduced ERN. The magnitude of neural reactivity to errors is sensitive to anxiety, depression, and development. Early physical maturation and anxiety may heighten neural sensitivity to errors yet predict opposing effects in the context of depression.

Indexed as

AdolescentAdultAnxiety DisordersCerebral CortexChildDepressionDepressive DisorderElectroencephalographyEvoked PotentialsFemaleHumansMalePsychomotor PerformancePubertyYoung AdultdepressionEEGerror-related negativitypediatric anxietypuberty

Identifiers

PMID30043447
PMCPMC6318038
OpenAlexW2883480093

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.