Evidence map›Paper›PMID 30043330›Full record

Trial reportInternational journal of hematology2018

Plerixafor for mobilization and collection of haematopoietic stem cells for autologous transplantation in Japanese patients with non-Hodgkin lymphoma: a randomized phase 2 study.

Kosei Matsue, Kyoya Kumagai, Isamu Sugiura, Takayuki Ishikawa, Tadahiko Igarashi, Tsutomu Sato, Michihiro Uchiyama, Toshihiro Miyamoto, Takaaki Ono, Yasunori Ueda and 4 more

Erratum issued Registry-linked trialAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International journal of hematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02221492 (A Randomized, Open-label, Two-arm Parallel Group, Comparative Study for Assessing the Clinical Benefit of Subcutaneous Injection of Plerixafor Plus G-CSF for Mobilization and Collection of Peripheral Hematopoietic Stem Cells in Japanese Patients With Non-Hodgkin Lymphoma), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02221492 phase2completednot on this map

A Randomized, Open-label, Two-arm Parallel Group, Comparative Study for Assessing the Clinical Benefit of Subcutaneous Injection of Plerixafor Plus G-CSF for Mobilization and Collection of Peripheral Hematopoietic Stem Cells in Japanese Patients With Non-Hodgkin Lymphoma

TypeinterventionalSponsorGenzyme, a Sanofi CompanyRan2014 to 2016Enrolled32ConditionsLymphomaArmsplerixafor GZ316455, Filgrastim
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Low Dose Cyclophospahamide is a Feasable Mobilization Regimen in the Covid-19 Era: A Single Center Study from Türkiye.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 13 institutions in 1 country.

Kosei MatsueDepartment of Hematology and Oncology, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba, 296-8602, Japan. koseimatsue@gmail.com.ORCID http://orcid.org/0000-0002-8669-9865
Kyoya KumagaiDivision of Hematology and Oncology, Chiba Cancer Center, Chiba, Japan.
Isamu SugiuraDepartment of Hematology & Oncology, Toyohashi Municipal Hospital, Toyohashi, Japan.
Takayuki IshikawaDepartment of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan.
Tadahiko IgarashiHematology/Oncology, Gunma Cancer Center, Ota, Japan.
Tsutomu SatoDepartment of Medical Oncology and Hematology, Sapporo Medical University Hospital, Sapporo, Japan.
Michihiro UchiyamaHematology and Oncology, Japanese Red Cross Society Suwa Hospital, Suwa, Japan.
Toshihiro MiyamotoMedicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takaaki OnoDepartment of Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Yasunori UedaDepartment of Haematology/Oncology, Kurashiki Central Hospital, Kurashiki, Japan.
Toru KiguchiDepartment of Hematology, Chugoku Central Hospital, Fukuyama, Japan.
Yoshinori SunagaSanofi K.K., Tokyo, Japan.
Toru SasakiSanofi K.K., Tokyo, Japan.
Kenshi SuzukiDepartment of Hematology, Mitsui Memorial Hospital, Tokyo, Japan.
Sanofi (Japan) · JPChiba Cancer Center · JPChugoku Central Hospital · JPGunma Children's Medical Center · JPHamamatsu University School of Medicine · JPJapanese Red Cross Medical Center · JPKameda Medical Center · JPKobe City Medical Center General Hospital · JPKurashiki Central Hospital · JPKyushu University · JPSapporo Medical University Hospital · JPSuwa Red Cross Hospital · JPToyohashi Municipal Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study (ClinicalTrials.gov Identifier: NCT02221492) was conducted to assess the efficacy and safety of plerixafor for the mobilization and collection of haematopoietic stem cells (HSCs) for autologous transplantation in Japanese non-Hodgkin lymphoma (NHL) patients. In this randomized phase 2 study, patients received granulocyte-colony stimulating factor (G-CSF, filgrastim) 400 µg/m²/day for up to 8 days. Starting on the evening of day 4, patients received, for up to 4 days, either plerixafor (240 µg/kg/day) in the G-CSF+ plerixafor arm (GP arm) or G-CSF alone arm (G arm). On day 5, daily apheresis started and was continued for up to 4 days, or until ≥ 5 × 10

Indexed as

Hematopoietic Stem CellsPeripheral Blood Stem Cell TransplantationAdultAgedAutograftsBenzylaminesCyclamsFemaleHematopoietic Stem Cell MobilizationHeterocyclic CompoundsHumansLymphoma, Non-HodgkinMaleMiddle AgedBenzylaminesCyclamsHeterocyclic CompoundsplerixaforApheresisG-CSFNon-Hodgkin’s lymphoma (NHL)PlerixaforStem cell

Identifiers

PMID30043330
OpenAlexW2883146146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.