Evidence map›Paper›PMID 30043322›Full record

ArticleProbiotics and antimicrobial proteins2019

Antimicrobial Activity of Selected Antimicrobial Peptides Against Planktonic Culture and Biofilm of Acinetobacter baumannii.

Maciej Jaśkiewicz, Damian Neubauer, Kamil Kazor, Sylwia Bartoszewska, Wojciech Kamysz

Open access · hybridAbstract read
In one paragraph

Article in Probiotics and antimicrobial proteins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. The intricacies ofFrontiers in microbiology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Effect of Camel Peptide on the Biofilm ofAntibiotics (Basel, Switzerland) · 2023
    Article
  10. Review
  11. Antibiofilm properties of cathelicidin LL-37: an in-depth review.World journal of microbiology & biotechnology · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. In vitro activity of the antimicrobial peptides h-Lf1-11, MSI-78, LL-37, fengycin 2B, and magainin-2 against clinically important bacteria.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022
    Article
  17. Review
  18. The In Vitro Ability ofPathogens (Basel, Switzerland) · 2021
    Article
  19. Antimicrobial Peptides: A Potent Alternative to Antibiotics.Antibiotics (Basel, Switzerland) · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Maciej JaśkiewiczDepartment of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland. mj@gumed.edu.pl.ORCID http://orcid.org/0000-0003-4797-2635
Damian NeubauerDepartment of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland.
Kamil KazorDepartment of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland.
Sylwia BartoszewskaDepartment of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland.
Wojciech KamyszDepartment of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland.
Gdańsk Medical University · PL

Funding

Medical University of Gdansk statutory grant ST-02-0087/07/508Polish Ministry of Science and Higher Education Grant for Young Investigators 01-0305/08/508
6 · The paper itself

Abstract

Acinetobacter baumannii is one of the most challenging pathogens, on account of its predisposition to develop resistance leading to severe, difficult-to-treat infections. As these bacteria are more usually isolated from nosocomial infections, the new therapeutic options are demanded. Antimicrobial peptides (AMPs) are compounds likely to find application in the treatment of A. baumannii. These compounds exhibit a wide spectrum of antimicrobial activity and were found to be effective against biofilm. In this study, eight AMPs, namely aurein 1.2, CAMEL, citropin 1.1., LL-37, omiganan, r-omiganan, pexiganan, and temporin A, were tested for their antimicrobial activity. A reference strain of A. baumannii ATCC 19606 was used. Antimicrobial assays included determination of the minimum inhibitory concentration and the minimum biofilm eradication concentration. Considering the fact that the majority of A. baumannii infections are associated with mechanical ventilation and the use of indwelling devices, the activity against biofilm was assessed on both a polystyrene surface and tracheal tube fragments. In addition, cytotoxicity (HaCaT) was determined and in vitro selectivity index was calculated.

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsBiofilmsCell Line, TumorCell SurvivalHumansMicrobial Sensitivity TestsPeptidesPlanktonAnti-Bacterial AgentsPeptidesAcinetobacter baumanniiAntibioticsAntimicrobial peptidesAntimicrobial susceptibility testingBiofilmPeptide drugsTracheal tubes

Identifiers

PMID30043322
PMCPMC6449538
OpenAlexW2884114264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.