ArticleAging clinical and experimental research2019
Infant and childhood growth and frailty in old age: the Helsinki Birth Cohort Study.
Article in Aging clinical and experimental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Mendelian randomization shows causal effects of birth weight and childhood body mass index on the risk of frailty.Frontiers in public health · 2024Article
- Understanding the Causes of Frailty Using a Life-Course Perspective: A Systematic Review.Healthcare (Basel, Switzerland) · 2023Review
- Body Composition in Late Midlife as a Predictor of Accelerated Age-associated Deficit-accumulation From Late Midlife into Old Age: A Longitudinal Birth Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Trajectories of physical and mental functioning over 25 years before onset of frailty: results from the Whitehall II cohort study.Journal of cachexia, sarcopenia and muscle · 2023Article
- Early-Life Factors as Predictors of Age-Associated Deficit Accumulation Across 17 Years From Midlife Into Old Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Physical capability in a rural birth cohort at the age of 52: association with early environmental, nutritional, and developmental factors.BMC geriatrics · 2022Article
- The degree of frailty as a translational measure of health in aging.Nature aging · 2021Review
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundEvidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases.
methodsIn this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years.
resultsGreater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls.
conclusionsMen who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.