ReviewBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2018
Iron metabolism in diabetes-induced Alzheimer's disease: a focus on insulin resistance in the brain.
Review in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Quantitative susceptibility mapping for iron monitoring of multiple subcortical nuclei in type 2 diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Association Between Deep Gray Matter Iron Deposition Dysregulation and Cognitive Performance in Type 2 Diabetes Mellitus Patients: A Quantitative Susceptibility Mapping Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Limbic-Predominant Cortical Magnetic Susceptibility Alterations Are Associated With Glycemic Dysregulation and Cognitive Performance in Type 2 Diabetes.CNS neuroscience & therapeutics · 2026Article
- The iron-energy metabolism axis in Alzheimer's pathogenesis: from mechanisms to interventions.Cell death discovery · 2026Review
- In newly diagnosed diabetes, hyperglycemia is associated with increased brain iron deposition, measured by MRI-based Quantitative Susceptibility Mapping (QSM).Journal of advanced research · 2026Article
- Age Estimation From Blood Test Results Using a Random Forest Model.Journal of clinical laboratory analysis · 2025Article
- Brain Iron Deposition Alterations in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment Based on Quantitative Susceptibility Mapping.Journal of diabetes · 2025Observational
- New Insights into the Role of SGLT-2 Inhibitors in the Prevention of Dementia.Neurology international · 2024Review
- Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review.Aging medicine (Milton (N.S.W)) · 2024Review
- Iron homeostasis and insulin sensitivity: unraveling the complex interactions.Reviews in endocrine & metabolic disorders · 2024Review
- Adipose knockout of H-ferritin improves energy metabolism in mice.Molecular metabolism · 2024Article
- Iron and Targeted Iron Therapy in Alzheimer's Disease.International journal of molecular sciences · 2023Review
- The Impact of Hydroxytyrosol on the Metallomic-Profile in an Animal Model of Alzheimer's Disease.International journal of molecular sciences · 2023Article
- The Role of Iron Overload in Diabetic Cognitive Impairment: A Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- Clinical antidiabetic medication used in Alzheimer's disease: From basic discovery to therapeutics development.Frontiers in aging neuroscience · 2023Review
- Article
- Brain Glucose Hypometabolism and Iron Accumulation in Different Brain Regions in Alzheimer's and Parkinson's Diseases.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Calcium chelator BAPTA‑AM protects against iron overload‑induced chondrocyte mitochondrial dysfunction and cartilage degeneration.International journal of molecular medicine · 2021Article
- Preparation of Multifunctional N-Doped Carbon Quantum Dots fromPharmaceuticals (Basel, Switzerland) · 2021Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is characterized by an excessive accumulation of toxic amyloid beta (Aβ) plaques and memory dysfunction. The onset of AD is influenced by age, genetic background, and impaired glucose metabolism in the brain. Several studies have demonstrated that diabetes involving insulin resistance and glucose tolerance could lead to AD, ultimately resulting in cognitive dysfunction. Even though the relationship between diabetes and AD was indicated by significant evidences, the critical mechanisms and metabolic alterations in diabetes induced AD are not clear until now. Recently, iron metabolism has been shown to play multiple roles in the central nervous system (CNS). Iron deficiency and overload are associated with neurodegenerative diseases. Iron binds to Aβ and subsequently regulates Aβ toxicity in the CNS. In addition, previous studies have shown that iron is involved in the aggravation of insulin resistance. Considering these effects of iron metabolism in CNS, we expect that iron metabolism may play crucial roles in diabetic AD brain. Thus, we review the recent evidence regarding the relationship between diabetes-induced AD and iron metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.