Evidence map›Paper›PMID 30043276›Full record

ReviewIntensive care medicine2018

Extracorporeal organ support (ECOS) in critical illness and acute kidney injury: from native to artificial organ crosstalk.

Faeq Husain-Syed, Zaccaria Ricci, Daniel Brodie, Jean-Louis Vincent, V Marco Ranieri, Arthur S Slutsky, Fabio Silvio Taccone, Luciano Gattinoni, Claudio Ronco

Abstract readReview
PubMed Publisher
In one paragraph

Review in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. COVID-19 associated acute kidney injury.Infectious diseases & immunity · 2025
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Organ crosstalk and dysfunction in sepsis.Annals of intensive care · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Faeq Husain-SyedDepartment of Internal Medicine II, Division of Nephrology, Pulmonology and Critical Care Medicine, University Clinic Giessen and Marburg-Campus Giessen, Klinikstrasse 33, 35392, Giessen, Germany. faeq.husain-syed@innere.med.uni-giessen.de.
Zaccaria RicciDepartment of Cardiology and Cardiac Surgery, Pediatric Cardiac Intensive Care Unit, Bambino Gesu Children's Hospital, IRCCS, Piazza di Sant'Onofrio 4, 00165, Rome, Italy.
Daniel BrodieDepartment of Medicine, Columbia University College of Physicians and Surgeons/New York-Presbyterian Hospital, 630 West 168th Street, PH8 East, Room 101, New York, NY, 10032, USA.
Jean-Louis VincentDepartment of Intensive Care, Erasme University Hospital, Route de Lennik 808, 1070, Brussels, Belgium.
V Marco RanieriAnesthesia and Intensive Care Medicine, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale DEL Policlinico 155, 00161, Rome, Italy.
Arthur S SlutskyInterdepartmental Division of Critical Care Medicine, Departments of Medicine, Surgery and Biomedical Engineering, University of Toronto, Toronto, Canada.
Fabio Silvio TacconeDepartment of Intensive Care, Erasme University Hospital, Route de Lennik 808, 1070, Brussels, Belgium.
Luciano GattinoniDepartment of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Robert-Koch-Strasse 40, 37075, Göttingen, Germany.
Claudio RoncoDepartment of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Via Rodolfi, 37, 36100, Vicenza, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complex nature of single organ failure potentially leading to multiple organ dysfunction syndrome (MODS) in critically ill patients necessitates integrated supportive therapy. Rather than a primary disease, acute kidney injury (AKI) is considered a window to a potentially serious underlying systemic disease, which may partially explain the high morbidity and mortality rates associated with the condition. Renal replacement therapy (RRT) has been routinely used for more than a decade in various intensive care settings and there has also been an increase in the use of extracorporeal membrane oxygenation and extracorporeal carbon dioxide removal. When these renal and cardiopulmonary modalities are used together, a multidisciplinary approach is necessary to minimize negative interactions and unwanted adverse effects. In this review, we describe the patterns of organ crosstalk between the native and artificial organs, the incidence of AKI and need for RRT and associated mortality after extracorporeal organ support (ECOS) therapy, including the potential short- and long-term advantages and disadvantages of organ support in terms of renal function. We also review potential indications of RRT outside its conventional indications in patients with MODS, as well as technical considerations when RRT is used alongside other organ support therapies. Overall, available literature has not definitely established the ideal timing of these interventions, and whether early implementation impacts organ recovery and optimizes resource utilization is still a matter of open debate: it is possible that future research will be devoted to identify patient groups that may benefit from short- and long-term multiple organ support.

Indexed as

Acute Kidney InjuryAnti-Bacterial AgentsAnticoagulantsArtificial OrgansCritical IllnessExtracorporeal Membrane OxygenationFluid TherapyHemodynamicsHemofiltrationHumansHypercapniaMultiple Organ FailureRenal Replacement TherapyRespiratory Distress SyndromeAnti-Bacterial AgentsAnticoagulantsAcute kidney injuryAcute respiratory distress syndromeCardiogenic shockExtracorporeal membrane oxygenationMultiple organ support therapyRenal replacement therapy

Identifiers

PMID30043276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.