ArticleEuropean radiology2019
Magnetic resonance elastography can predict development of hepatocellular carcinoma with longitudinally acquired two-point data.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 35 citations in OpenAlex.
- Association Between Early and Long-Term Changes in Liver Stiffness in Patients with MASLD Undergoing Serial Magnetic Resonance Elastography.Diagnostics (Basel, Switzerland) · 2026Article
- MR elastography-based prediction of development of hepatocellular carcinoma in patients with chronic hepatitis B with sustained virological response.European radiology · 2025Article
- Preoperative Multifrequency MR Elastography for Stratifying Wnt/β-Catenin Pathway and Microvascular Invasion Phenotypes in Hepatocellular Carcinoma.Journal of magnetic resonance imaging : JMRI · 2025Article
- MR Elastography for Classification of Focal Liver Lesions Using Viscoelastic Parameters: A Pilot Study Based on Intrinsic and Extrinsic Activations.Journal of magnetic resonance imaging : JMRI · 2025Article
- CAFs activated by YAP1 upregulate cancer matrix stiffness to mediate hepatocellular carcinoma progression.Journal of translational medicine · 2025Article
- Linking cell mechanical memory and cancer metastasis.Nature reviews. Cancer · 2024Review
- Review
- Noninvasive Fibrosis Assessment in Chronic Hepatitis C Infection: An Update.Journal of clinical and translational hepatology · 2023Review
- Review
- Liver fibrosis assessment: MR and US elastography.Abdominal radiology (New York) · 2022Review
- Liver stiffness in magnetic resonance elastography is prognostic for sorafenib-treated advanced hepatocellular carcinoma.European radiology · 2021Article
- Up-to-Date Role of CT/MRI LI-RADS in Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2021Review
- MR elastography of liver: current status and future perspectives.Abdominal radiology (New York) · 2020Review
- Liver stiffness measured by MR elastography is a predictor of early HCC recurrence after treatment.European radiology · 2020Article
- Comparison between ROI-based and volumetric measurements in quantifying heterogeneity of liver stiffness using MR elastography.European radiology · 2020Article
- Magnetic Resonance Elastography for the Clinical Risk Assessment of Fibrosis, Cirrhosis, and Portal Hypertension in Patients With NAFLD.Journal of clinical and experimental hepatologyReview
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the usefulness of longitudinal observation of liver stiffness measured using magnetic resonance elastography (MRE) to stratify the risk of hepatocellular carcinoma (HCC) in patients with chronic liver disease. MATERIALS AND
methodsWe retrospectively reviewed data for 161 patients with chronic liver disease using the following inclusion criteria: two MRE examinations separated by at least a 12-month interval, no history of HCC, no development of HCC between the two examinations and availability of laboratory results. Liver stiffness was classified as low (< 3 kPa), moderate (3-4.7 kPa) or high (> 4.7 kPa). The patients were divided into three groups according to sequential changes in liver stiffness as follows: high on the first MRE (group A, n = 60), low on both MRE examinations (group C, n = 36) and other combinations (group B, n = 65). Cox analyses and Kaplan-Meier methods were used to determine the risk of developing HCC.
resultsForty-seven patients (29.2%) developed HCC during follow-up (46.7% [28/60] in group A, 26.2% [17/65] in group B, and 5.6% [2/36] in group C). There was a significant difference in the rate of development of HCC between groups A (45.1%), B (26.1%) and C (12.4%) at 3 years (p = 0.0002). The independent risk factors for development of HCC were group A classification, age and a high alanine aminotransferase level (risk ratio 1.018-6.030; p = 0.0028-0.0268).
conclusionLongitudinal observation of liver stiffness using MRE can stratify the risk of HCC during follow-up of chronic liver disease. KEY POINTS: • The results of MRE can stratify the risk for development of HCC during follow-up in patients with chronic liver disease. • Patients with chronic liver disease and high liver stiffness (> 4.7 kPa) on a previous MRE examination are at high risk for developing HCC, regardless of current liver stiffness. • Management of patients with chronic liver disease becomes more appropriate using longitudinally acquired two-point MRE data.
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