Evidence map›Paper›PMID 30043082›Full record

Trial reportDysphagia2019

Poor Relationship Between Fractionated Exhaled Nitric Oxide and Disease Activity in Eosinophilic Esophagitis.

Kimberly Johnson, Vivek Iyer, David Katzka, Karthik Ravi, Ryan Lennon, Richard Pendegraft, Debra Geno, Jeffrey Alexander

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Dysphagia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Shifting the scope: Moving toward less invasive diagnosis and monitoring of eosinophilic esophagitis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. EoE disease monitoring: Where we are and where we are going.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kimberly JohnsonInternal Medicine, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN, 55905, USA.
Vivek IyerPulmonary and Critical Care Medicine, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN, 55905, USA.
David KatzkaGastroenterology and Hepatology, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN, 55905, USA.
Karthik RaviGastroenterology and Hepatology, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN, 55905, USA.
Ryan LennonMayo Clinic Rochester, 200 First Street SW, Rochester, MN, 55905, USA.
Richard PendegraftMayo Clinic Rochester, 200 First Street SW, Rochester, MN, 55905, USA.
Debra GenoMayo Clinic Rochester, 200 First Street SW, Rochester, MN, 55905, USA.
Jeffrey AlexanderGastroenterology and Hepatology, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN, 55905, USA. alexander.jeffrey14@mayo.edu.
Mayo Clinic · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Mayo Clinic CTSA from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH) UL1 TR000135
6 · The paper itself

Abstract

Current eosinophilic esophagitis care requires monitoring with repeat endoscopy and biopsy, which has significant cost, risk, and inconvenience for patients. Fractionated exhaled nitric oxide testing (FeNO) is a standardized non-invasive test with proven utility in evaluation of asthma. Elevated FeNO has reported use in other eosinophilic inflammatory conditions; however, its use in eosinophilic esophagitis has not been fully evaluated. To assess the utility of FeNO in predicting severity of eosinophilic esophagitis activity. Fifty patients received fractionated exhaled nitric oxide testing within 1 week of endoscopic evaluation with biopsy for determination of peak eosinophil counts. Presence of furrows was also evaluated with respect to FeNO levels. Spearman correlation was calculated between FeNO and peak eosinophil counts (PEC) with subgroup analysis performed based on PPI use. Spearman correlation was performed on the change in FeNO and PEC on the patients receiving repeat testing. FeNO was poorly correlated to PEC (Spearman correlation 0.22). With a cut-off FeNO value of > 40 ppb, specificity of FeNO for detecting presence of ≥ 15 eos/hpf was 0.94 and sensitivity was 0.16. FeNO showed weak relationship to presence of furrows. Within the subgroup of patients not taking PPI, the spearman correlation was 0.21. Delta- FeNO versus Delta-PEC had spearman correlation of 0.72 for patients receiving repeat testing. FeNO likely has limited clinical utility for predicting severity of esophageal eosinophilia. In patients with FeNO levels > 40 ppb, specificity of testing was high, but very few patients reached this FeNO level.

Indexed as

EosinophilsAdolescentAdultAgedBreath TestsEosinophilic EsophagitisExhalationFemaleHumansLeukocyte CountMaleMiddle AgedNitric OxidePilot ProjectsProspective StudiesRespiratory Function TestsNitric OxideDeglutitionDeglutition disordersEosinophilsEosinophils esophagitisNitric oxide

Identifiers

PMID30043082
OpenAlexW2884369016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.