Evidence map›Paper›PMID 30042881›Full record

ArticlePeerJ2018

Achilles and tail tendons of perlecan exon 3 null heparan sulphate deficient mice display surprising improvement in tendon tensile properties and altered collagen fibril organisation compared to C57BL/6 wild type mice.

Cindy C Shu, Margaret M Smith, Richard C Appleyard, Christopher B Little, James Melrose

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. The "other" 15-40%: The Role of Non-Collagenous Extracellular Matrix Proteins and Minor Collagens in Tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Review
  6. Biomechanical Testing of Murine Tendons.Journal of visualized experiments : JoVE · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Cindy C ShuRaymond Purves Bone and Joint Laboratory, Kolling Institute of Medical Research, University of Sydney, Australia.
Margaret M SmithRaymond Purves Bone and Joint Laboratory, Kolling Institute of Medical Research, University of Sydney, Australia.
Richard C AppleyardMurray Maxwell Biomechanics Laboratory, Royal North Shore Hospital, University of Sydney, St. Leonards, New South Wales, Australia.
Christopher B LittleRaymond Purves Bone and Joint Laboratory, Kolling Institute of Medical Research, University of Sydney, Australia.
James MelroseRaymond Purves Bone and Joint Laboratory, Kolling Institute of Medical Research, University of Sydney, Australia.
Northern Sydney Local Health District · AUUniversity of Sydney · AUMacquarie University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to determine the role of the perlecan (Hspg2) heparan sulphate (HS) side chains on cell and matrix homeostasis in tail and Achilles tendons in 3 and 12 week old

Indexed as

BiomechanicsCollagenExtracellular matrixFibroblast growth factorHeparan sulphateProteoglycanTendonTenocyte

Identifiers

PMID30042881
PMCPMC6056265
OpenAlexW2810194285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.