ReviewAmerican journal of nuclear medicine and molecular imaging2018
X-ray fluorescence imaging of metals and metalloids in biological systems.
Review in American journal of nuclear medicine and molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- The arsenic proteome in cancer: Unravelling molecular mechanisms of anticancer drugs.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Review
- Metallomic Analysis of Vitreous Humor of the Human Eye-A Post-Mortem Multielemental Study.International journal of molecular sciences · 2026Article
- CT-Based Attenuation Correction Algorithm for Quantitative L-Shell X-Ray Fluorescence Imaging of Gold Nanoparticles in Murine Tumor Tissues.Diseases (Basel, Switzerland) · 2025Article
- Ampicillin-derived carbon dots as the sensitive probe for the detection of FeMikrochimica acta · 2024Article
- Unveiling breast cancer metastasis through an advanced X-ray imaging approach.Scientific reports · 2024Article
- PbSensors (Basel, Switzerland) · 2024Article
- Self-absorption correction on 2D X-ray fluorescence maps.Scientific reports · 2023Article
- Elemental profiles in distant tissues during tumor progression.BMC cancer · 2023Article
- Review
- Engineered lanthanide-doped upconversion nanoparticles for biosensing and bioimaging application.Mikrochimica acta · 2022Review
- Iron and Alzheimer's Disease: From Pathology to Imaging.Frontiers in human neuroscience · 2022Review
- X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study.Cancers · 2021Article
- Synchrotron fluorescence imaging of individual mouse beta-cells reveals changes in zinc, calcium, and iron in a model of low-grade inflammation.Metallomics : integrated biometal science · 2021Article
- Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids.RSC advances · 2021Article
- Review of in vivo optical molecular imaging and sensing from x-ray excitation.Journal of biomedical optics · 2021Review
- Combined Metallomics/Transcriptomics Profiling Reveals a Major Role for Metals in Wound Repair.Frontiers in cell and developmental biology · 2021Article
- Engineering multifunctional metal/protein hybrid nanomaterials as tools for therapeutic intervention and high-sensitivity detection.Chemical science · 2020Article
- Identification of Ca-rich dense granules in human platelets using scanning transmission X-ray microscopy.Journal of synchrotron radiation · 2020Article
- Subcellular Localization of Copper-Cellular Bioimaging with Focus on Neurological Disorders.International journal of molecular sciences · 2020Review
- Analysis of trace elements in human hair through X-ray fluorescence spectroscopy for screening of prostate cancer.Medical journal of the Islamic Republic of Iran · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metals and metalloids play fundamental roles in many physiological processes in biological systems, but imbalance of these elements in the body may cause many diseases, such as Parkinson's disease, Alzheimer's disease, and even cancers. Thus, to better understand the metallome in health and disease, quantitative determination of their localization, concentration, speciation, and related metabolism at cellular or subcellular levels is of great importance. X-ray fluorescence (XRF) imaging, as a new generation of analytical technique, has been reported as an ideal tool to quantitatively map multiple metals and metalloids in tissues with reasonable sensitivity, specificity, and resolution. In the current review, we have introduced the general concept of XRF imaging technique, reviewed the recent advances using XRF imaging to investigate toxicology of metals and metalloids in life science, and discussed the roles of metals and metalloids in various diseases, including cancers and neurodegenerative diseases. We believe that future research on revealing the roles of metals and metalloids in biological systems will directly benefit from the important breakthroughs in developing XRF imaging techniques.
Indexed as
Identifiers
30042869PMC6056246W2917627184What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.