Evidence map›Paper›PMID 30042737›Full record

ArticleFrontiers in endocrinology2018

Recombinant FSH Improves Sperm DNA Damage in Male Infertility: A Phase II Clinical Trial.

Nicola Colacurci, Vincenzo De Leo, Giovanni Ruvolo, Paola Piomboni, Francesca Caprio, Rosario Pivonello, Enrico Papaleo, Eugenio La Verde, Raffaella Depalo, Monica Lispi and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
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  13. Combined Effects of theThe world journal of men's health · 2021
    Article
  14. Article
  15. FSH for the Treatment of Male Infertility.International journal of molecular sciences · 2020
    Review
  16. Cytochemical tests to investigate sperm DNA damage: Assessment and review.Journal of family medicine and primary care · 2019
    Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Nicola ColacurciDepartment of Gynecological, Obstetrics and Reproduction Sciences, II University of Naples, Naples, Italy.
Vincenzo De LeoDepartment of Molecular and Developmental Medicine, Centre for Couple Sterility, University of Siena, Siena, Italy.
Giovanni RuvoloObstetrics and Gynecology, Casa di Cura Candela, Palermo, Italy.
Paola PiomboniDepartment of Molecular and Developmental Medicine, Centre for Couple Sterility, University of Siena, Siena, Italy.
Francesca CaprioDepartment of Gynecological, Obstetrics and Reproduction Sciences, II University of Naples, Naples, Italy.
Rosario PivonelloDepartment of Endocrinology, University of Naples "Federico II", Naples, Italy.
Enrico PapaleoOperating Unit of Gynecology and Obstetrics, DIMER Center of Natality Sciences, IRCCS San Raffaele of Milan, Milan, Italy.
Eugenio La VerdeDepartment of Gynecological, Obstetrics and Reproduction Sciences, II University of Naples, Naples, Italy.
Raffaella DepaloPathophysiology Center of Human Reproduction and Freezing Gametes, Ospedale Policlinico Consorziale of Bari, Bari, Italy.
Monica LispiMerck Serono S.p.A, Rome, Italy.
Salvatore LongobardiMerck Serono S.p.A, Rome, Italy.
Donatella PaoliLaboratory of Seminology- Sperm Bank "Loredana Gandini", Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Francesco PallottiLaboratory of Seminology- Sperm Bank "Loredana Gandini", Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Francesco LombardoLaboratory of Seminology- Sperm Bank "Loredana Gandini", Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
University of Naples Federico II · ITSapienza University of Rome · ITMerck Serono (Italy) · ITUniversity of Siena · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

trial registrationEUDRACT Number 2010-020196-23. Registred 14 April 2011.

Indexed as

DNA fragmentation indexfunctional hypogonadotropic hypogonadismmale infertilityrecombinant FSHsperm DNA fragmentation

Identifiers

PMID30042737
PMCPMC6048873
OpenAlexW2811169427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.