ArticleFrontiers in neurology2018
Differences in Cortical Structure and Functional MRI Connectivity in High Functioning Autism.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Cortical thickness abnormalities in autism spectrum disorder.European child & adolescent psychiatry · 2024Pooled it
- A meta-analytic investigation of grey matter differences in anorexia nervosa and autism spectrum disorder.European eating disorders review : the journal of the Eating Disorders Association · 2022Pooled it
- Cortical Gyrification Morphology in Individuals with ASD and ADHD across the Lifespan: A Systematic Review and Meta-Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2021Pooled it
- Comparative meta-analyses of brain structural and functional abnormalities during cognitive control in attention-deficit/hyperactivity disorder and autism spectrum disorder.Psychological medicine · 2020Pooled it
- Cross-attention-guided subject-adaptive graph learning for multimodal autism classification: integrating structural and functional MRI data.Brain informatics · 2026Article
- Aberrant multivariate mapping between behavioral profiles and cortical morphological brain networks in children with autism spectrum disorder.Translational psychiatry · 2026Article
- Integrating Multimodal Neuroimaging and Physical-Health Markers for Autism Spectrum Disorder in the ABCD Study.Journal of integrative neuroscience · 2026Article
- Common and distinct changes of regional resting-state brain activity between high- and low-functioning autism spectrum disorder.BMC psychiatry · 2026Article
- Cortical Thickness and Curvature in Autism and ADHD: A Mega-Analysis.bioRxiv : the preprint server for biology · 2026Article
- Overlapping and distinct intrinsic connectivity of hippocampal and triple networks in autistic individuals with and without a comorbid condition of ADHD.Frontiers in psychiatry · 2026Article
- Salience Network in Autism: preliminary results on functional connectivity analysis in resting state.European archives of psychiatry and clinical neuroscience · 2025Article
- Review
- Associations between sleep problems, cortical morphometry, and structural brain network organization in preschool children with autism: a retrospective observational study.European journal of pediatrics · 2025Observational
- [Neurodevelopment and cerebral blood flow in children aged 2-6 years with autism spectrum disorder].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Using adaptive behavior scores to convey level of functioning in children with autism spectrum disorder: Evidence from the Study to Explore Early Development.Autism : the international journal of research and practice · 2024Article
- Functional brain network alterations in the co-occurrence of autism spectrum disorder and attention deficit hyperactivity disorder.European child & adolescent psychiatry · 2024Article
- Deep learning based joint fusion approach to exploit anatomical and functional brain information in autism spectrum disorders.Brain informatics · 2024Article
- Age-related differences in the intrinsic connectivity of the hippocampus and ventral temporal lobe in autistic individuals.Frontiers in human neuroscience · 2024Article
- 3D CNN for neuropsychiatry: Predicting Autism with interpretable Deep Learning applied to minimally preprocessed structural MRI data.PloS one · 2024Article
- Neuroimaging Insights into Autism Spectrum Disorder: Structural and Functional Brain.Health psychology research · 2024Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorders (ASD) represent a complex group of neurodevelopmental conditions characterized by deficits in communication and social behaviors. We examined the functional connectivity (FC) of the default mode network (DMN) and its relation to multimodal morphometry to investigate superregional, system-level alterations in a group of 22 adolescents and young adults with high-functioning autism compared to age-, and intelligence quotient-matched 29 healthy controls. The main findings were that ASD patients had gray matter (GM) reduction, decreased cortical thickness and larger cortical surface areas in several brain regions, including the cingulate, temporal lobes, and amygdala, as well as increased gyrification in regions associated with encoding visual memories and areas of the sensorimotor component of the DMN, more pronounced in the left hemisphere. Moreover, patients with ASD had decreased connectivity between the posterior cingulate cortex, and areas of the executive control component of the DMN and increased FC between the anteromedial prefrontal cortex and areas of the sensorimotor component of the DMN. Reduced cortical thickness in the right inferior frontal lobe correlated with higher social impairment according to the scores of the Autism Diagnostic Interview-Revised (ADI-R). Reduced cortical thickness in left frontal regions, as well as an increased cortical thickness in the right temporal pole and posterior cingulate, were associated with worse scores on the communication domain of the ADI-R. We found no association between scores on the restrictive and repetitive behaviors domain of ADI-R with structural measures or FC. The combination of these structural and connectivity abnormalities may help to explain some of the core behaviors in high-functioning ASD and need to be investigated further.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.