ArticleFrontiers in pharmacology2018
First Case in Italy of Fatal Intoxication Involving the New Opioid U-47700.
Article in Frontiers in pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Pharmacotherapy of Patients Taking New Psychoactive Substances: A Systematic Review and Analysis of Case Reports.Frontiers in psychiatry · 2021Pooled it
- Identification and Characterization of the Designer Opioid N-Pyrrolidino Fluetonitazene in Nasal Spray.Drug testing and analysis · 2026Article
- Review
- Intoxications involving methoxyacetylfentanyl and U-47700: a study of 3 polydrug fatalities.International journal of legal medicine · 2024Article
- Blood concentrations of new synthetic opioids.International journal of legal medicine · 2022Review
- Fatal cases involving new psychoactive substances and trends in analytical techniques.Frontiers in toxicology · 2022Review
- Untargeted Metabolomics in Forensic Toxicology: A New Approach for the Detection of Fentanyl Intake in Urine Samples.Molecules (Basel, Switzerland) · 2021Article
- Hair analysis for New Psychoactive Substances (NPS): Still far from becoming the tool to study NPS spread in the community?Toxicology reports · 2021Article
- Spectral trends in GC-EI-MS data obtained from the SWGDRUG mass spectral library and literature: A resource for the identification of unknown compounds.Forensic chemistry (Amsterdam, Netherlands) · 2020Article
- U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market.Brain sciences · 2020Review
- Pharmacodynamics and pharmacokinetics of the novel synthetic opioid, U-47700, in male rats.Neuropharmacology · 2020Article
- Toward the Interpretation of Positive Testing for Fentanyl and Its Analogs in Real Hair Samples: Preliminary Considerations.Journal of analytical toxicology · 2020Article
- Novel Opioids: Systematic Web Crawling Within the e-Psychonauts' Scenario.Frontiers in neuroscience · 2020Article
- New Psychoactive Substances: A Matter of Time.Current neuropharmacology · 2019Article
- The search for the "next" euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning.Forensic toxicology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The drug commonly known as U-47700 is a strong μ-opioid agonist with an approximate potency 7.5 times higher than morphine. It has been available in Europe since 2014, where it is usually sold through the internet or black market as an abuse morphine-like substance. In the case reported here, a Caucasian man was found dead in his apartment. Next to the body, the police seized one transparent plastic bag containing a white powder and two amber glass bottles with nasal spray containing few milliliters of a transparent liquid. During the autopsy, no evidence of natural disease or trauma was found to account for the death. Blood, urine and pubic hair were collected and submitted for toxicological analysis. The content of the seized materials was also submitted to a general screening analysis in order to determine its composition. U-47700 was detected in blood, urine and hair samples using an UHPLC/MS-MS method purposely developed. The blood and urine concentrations were 380 and 10,400 ng/mL, respectively. No other drugs of abuse nor ethanol were found in blood and urine specimens. Pubic hair analysis revealed a frequent past exposure to U-47700. Finally, U-47700 was identified as the main component of the powder and the liquids contained in the nasal spray bottles. The combined circumstantial elements and toxicological results of the case revealed the occurrence of an acute intoxication produced by U-47700 abuse. To the best of our knowledge, this is the first fatal intoxication case reported on the Italian territory involving the synthetic opioid U-47700.
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