ArticleFrontiers in human neuroscience2018
Extrahippocampal Contributions to Age-Related Changes in Spatial Navigation Ability.
Article in Frontiers in human neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Associations of mobility and frailty risk with wayfinding ability in aging.Behavioral neuroscience · 2026Article
- Spatial navigation strategy in older adults: Preference or ability?Psychology and aging · 2025Article
- Age- and sex-related differences in landmark recall following a virtual spatial navigation task.Frontiers in aging neuroscience · 2025Article
- Cardiorespiratory fitness is associated with cortical thickness of medial temporal brain areas associated with spatial cognition in young but not older adults.The European journal of neuroscience · 2024Article
- Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models.Frontiers in neural circuits · 2024Review
- Grid cells: the missing link in understanding Parkinson's disease?Frontiers in neuroscience · 2024Article
- Less spatial exploration is associated with poorer spatial memory in midlife adults.Frontiers in aging neuroscience · 2024Article
- Visual-spatial processing impairment in the occipital-frontal connectivity network at early stages of Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Enhancing spatial navigation skills in mild cognitive impairment patients: a usability study of a new version of ANTaging software.Frontiers in human neuroscience · 2023Article
- Can the Virtual Reality-Based Spatial Memory Test Better Discriminate Mild Cognitive Impairment than Neuropsychological Assessment?International journal of environmental research and public health · 2022Article
- Cardiorespiratory fitness is associated with fMRI signal in right cerebellum lobule VIIa Crus I and II during spatial navigation in older adult women.Frontiers in aging neuroscience · 2022Article
- Noise exposure in early adulthood causes age-dependent and brain region-specific impairments in cognitive function.Frontiers in neuroscience · 2022Article
- Future trends in brain aging research: Visuo-cognitive functions at stake during mobility and spatial navigation.Aging brain · 2022Review
- Self-Reported Sense of Direction and Vestibular Function in the Baltimore Longitudinal Study of Aging (BLSA).Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Spatial Navigation Is Impaired in Elderly Patients With Cerebral Small Vessel Disease.Frontiers in neurology · 2021Article
- Age-Related Differences in Resting-State EEG and Allocentric Spatial Working Memory Performance.Frontiers in aging neuroscience · 2021Article
- Requirements of a cognitive-motor spatial orientation training for nursing home residents: an iterative feasibility study.German journal of exercise and sport research · 2021Article
- A novel virtual-reality-based route-learning test suite: Assessing the effects of cognitive aging on navigation.Behavior research methods · 2020Article
- Differences in Encoding Strategy as a Potential Explanation for Age-Related Decline in Place Recognition Ability.Frontiers in psychology · 2020Article
- Differential Brain Activity in Regions Linked to Visuospatial Processing During Landmark-Based Navigation in Young and Healthy Older Adults.Frontiers in human neuroscience · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related decline in spatial navigation is well-known and the extant literature emphasizes the important contributions of a hippocampus-dependent spatial navigation system in mediating this decline. However, navigation is a multifaceted cognitive domain and some aspects of age-related navigational decline may be mediated by extrahippocampal brain regions and/or systems. The current review presents an overview of some key cognitive domains that contribute to the age-related changes in spatial navigation ability, and elucidates such domains in the context of an increased engagement of navigationally relevant extrahippocampal brain regions with advancing age. Specifically, this review focuses on age-related declines in three main areas: (i) allocentric strategy use and switching between egocentric and allocentric strategies, (ii) associative learning of landmarks/locations and heading directions, and (iii) executive functioning and attention. Thus far, there is accumulating neuroimaging evidence supporting the functional relevance of the striatum for egocentric/response strategy use in older adults, and of the prefrontal cortex for mediating executive functions that contribute to successful navigational performance. Notably, the functional role of the prefrontal cortex was particularly emphasized via the proposed relevance of the fronto-locus coeruleus noradrenergic system for strategy switching and of the fronto-hippocampal circuit for landmark-direction associative learning. In view of these putative prefrontal contributions to navigation-related functions, we recommend future spatial navigation studies to adopt a systems-oriented approach that investigates age-related alterations in the interaction between the prefrontal cortex, the hippocampus, and extrahippocampal regions, as well as an individual differences approach that clarifies the differential engagement of prefrontal executive processes among older adults.
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