ArticleScientific reports2018
Whole genome SNP-associated signatures of local adaptation in honeybees of the Iberian Peninsula.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Genomic and Morphological Insights Into the Adaptive Evolution of Honeybees in Rocky Desertification Habitats.Ecology and evolution · 2026Article
- Population Genetic Study ofEcology and evolution · 2026Article
- Mapping genomic adaptation to environmental heterogeneity in Indian native goat populations through landscape genomics.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- The diversity of insecticide target site mutations in Apis mellifera.BMC genomics · 2026Article
- Contrasting whole-genome diversity patterns and adaptation in honeybees from two southern European glacial refugia.iScience · 2026Article
- Signals of Ancestry-Specific Selection in Gentle Africanized Honey Bees.Genome biology and evolution · 2025Article
- Integrative Genomics Refines Tissues, Candidate Genes and Putative Regulatory Links Involved in the Humic Adaptation of Keystone Freshwater Fish.Molecular ecology · 2025Article
- Climate change-induced stress in the honey beeFrontiers in physiology · 2025Review
- Pathogen and Hemocyte Dynamics in Three Apiaries Across a Bee Season.Transboundary and emerging diseases · 2025Article
- HBeeID: a molecular tool that identifies honey bee subspecies from different geographic populations.BMC bioinformatics · 2024Article
- Genetic differentiation and local adaptation of the Japanese honeybee,Ecology and evolution · 2023Article
- The impact of geography and climate on the population structure and local adaptation in a wild bee.Evolutionary applications · 2023Article
- AmelHap: Leveraging drone whole-genome sequence data to create a honey bee HapMap.Scientific data · 2023Article
- Deciphering local adaptation of native Indian cattle (3 Biotech · 2023Article
- Complex population structure and haplotype patterns in the Western European honey bee from sequencing a large panel of haploid drones.Molecular ecology resources · 2022Article
- Article
- Assessment of genetic variation inSaudi journal of biological sciences · 2021Article
- A SNP assay for assessing diversity in immune genes in the honey bee (Apis mellifera L.).Scientific reports · 2021Article
- Mitochondrial DNA Variation in Peruvian Honey Bee (Insects · 2021Article
- Conservation insights from wild bee genetic studies: Geographic differences, susceptibility to inbreeding, and signs of local adaptation.Evolutionary applications · 2021Review
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6 authors.
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Abstract
The availability of powerful high-throughput genomic tools, combined with genome scans, has helped identifying genes and genetic changes responsible for environmental adaptation in many organisms, including the honeybee. Here, we resequenced 87 whole genomes of the honeybee native to Iberia and used conceptually different selection methods (Samβada, LFMM, PCAdapt, iHs) together with in sillico protein modelling to search for selection footprints along environmental gradients. We found 670 outlier SNPs, most of which associated with precipitation, longitude and latitude. Over 88.7% SNPs laid outside exons and there was a significant enrichment in regions adjacent to exons and UTRs. Enrichment was also detected in exonic regions. Furthermore, in silico protein modelling suggests that several non-synonymous SNPs are likely direct targets of selection, as they lead to amino acid replacements in functionally important sites of proteins. We identified genomic signatures of local adaptation in 140 genes, many of which are putatively implicated in fitness-related functions such as reproduction, immunity, olfaction, lipid biosynthesis and circadian clock. Our genome scan suggests that local adaptation in the Iberian honeybee involves variations in regions that might alter patterns of gene expression and in protein-coding genes, which are promising candidates to underpin adaptive change in the honeybee.
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