ArticleScientific reports2018
Quad-mode functional and molecular photoacoustic microscopy.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Fully integrated photoacoustic microscopy for multi-scale and longitudinal imaging in translational biomedical applications.Biomedical optics express · 2026Article
- Wide-Field High-Speed Scanning Acoustic/Photoacoustic Microscopy for Whole-Body Imaging of Small Animals.Biosensors · 2025Article
- Broadband transparent ultrasound transducer with polymethyl methacrylate as matching layer forPhotoacoustics · 2023Article
- Visualizing tumor angiogenesis and boundary with polygon-scanning multiscale photoacoustic microscopy.Photoacoustics · 2022Article
- Transgenic mice encoding modern imaging probes: Properties and applications.Cell reports · 2022Review
- Performance comparison of high-speed photoacoustic microscopy: opto-ultrasound combiner versus ring-shaped ultrasound transducer.Biomedical engineering letters · 2022Article
- Detection of weak optical absorption by optical-resolution photoacoustic microscopy.Photoacoustics · 2022Article
- Ultra-widefield photoacoustic microscopy with a dual-channel slider-crank laser-scanning apparatus forPhotoacoustics · 2021Article
- Deep image prior for undersampling high-speed photoacoustic microscopy.Photoacoustics · 2021Article
- Clear cell renal cell carcinoma detection by multimodal photoacoustic tomography.Photoacoustics · 2021Article
- Reconstructing Undersampled Photoacoustic Microscopy Images Using Deep Learning.IEEE transactions on medical imaging · 2021Article
- Convolutional neural network for resolution enhancement and noise reduction in acoustic resolution photoacoustic microscopy.Biomedical optics express · 2020Article
- GPU-accelerated 3D volumetric X-ray-induced acoustic computed tomography.Biomedical optics express · 2020Article
- Sensitivity Enhanced Photoacoustic Imaging Using a High-Frequency PZT Transducer with an Integrated Front-End Amplifier.Sensors (Basel, Switzerland) · 2020Article
- Optical-Resolution Photoacoustic Microscopy Using Transparent Ultrasound Transducer.Sensors (Basel, Switzerland) · 2019Article
- Simultaneous photoacoustic imaging of intravascular and tissue oxygenation.Optics letters · 2019Article
- Non-invasive imaging in dermatology and the unique potential of raster-scan optoacoustic mesoscopy.Journal of the European Academy of Dermatology and Venereology : JEADV · 2019Review
- Combining near-infrared fluorescence with Brainbow to visualize expression of specific genes within a multicolor context.Molecular biology of the cell · 2019Article
- Super-resolution localization photoacoustic microscopy using intrinsic red blood cells as contrast absorbers.Light, science & applications · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
A conventional photoacoustic microscopy (PAM) system typically has to make tradeoffs between its spatial resolution and penetration depth, by choosing a fixed configuration of optical excitation and acoustic detection. The single-scale imaging capability of PAM may limit its applications in biomedical studies. Here, we report a quad-mode photoacoustic microscopy (QM-PAM) system with four complementary spatial resolutions and maximum penetration depths. For this we first developed a ring-shaped focused ultrasound transducer that has two independent elements with respective central frequencies at 20 MHz and 40 MHz, providing complementary acoustically-determined spatial resolutions and penetration depths. To accommodate the dual-element ultrasound transducer, we implemented two optical excitation modes to provide tightly- and weakly-focused light illumination. The dual-element acoustic detection combined with the two optical focusing modes can thus provide four imaging scales in a single imaging device, with consistent contrast mechanisms and co-registered field of views. We have demonstrated the multiscale morphological, functional, and molecular imaging capability of QM-PAM in the mouse head, leg and ear in vivo. We expect the high scale flexibility of QM-PAM will enable broad applications in preclinical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.