Evidence map›Paper›PMID 30042336›Full record

ArticleInternational journal of molecular sciences2018

Conjugation with Dihydrolipoic Acid Imparts Caffeic Acid Ester Potent Inhibitory Effect on Dopa Oxidase Activity of Human Tyrosinase.

Raffaella Micillo, Julia Sirés-Campos, José Carlos García-Borrón, Lucia Panzella, Alessandra Napolitano, Conchi Olivares

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Pecan (ACS sustainable chemistry & engineering · 2020
    Article
  6. Skin Pigmentation: Is the Control of Melanogenesis a Target within Reach?International journal of molecular sciences · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Raffaella MicilloDepartment of Chemical Sciences, University of Naples Federico II, Via Cintia 4, I-80126 Naples, Italy. raffaella.micillo@unina.it.ORCID 0000-0002-4278-745X
Julia Sirés-CamposDepartment of Biochemistry and Molecular Biology, School of Medicine, University of Murcia and Instituto Murciano de Investigación Biosanitaria (IMIB), 30120 El Palmar, Spain. juliasc@um.es.ORCID 0000-0001-7635-6028
José Carlos García-BorrónDepartment of Biochemistry and Molecular Biology, School of Medicine, University of Murcia and Instituto Murciano de Investigación Biosanitaria (IMIB), 30120 El Palmar, Spain. gborron@um.es.
Lucia PanzellaDepartment of Chemical Sciences, University of Naples Federico II, Via Cintia 4, I-80126 Naples, Italy. panzella@unina.it.ORCID 0000-0002-2662-8205
Alessandra NapolitanoDepartment of Chemical Sciences, University of Naples Federico II, Via Cintia 4, I-80126 Naples, Italy. alesnapo@unina.it.ORCID 0000-0003-0507-5370
Conchi OlivaresDepartment of Biochemistry and Molecular Biology, School of Medicine, University of Murcia and Instituto Murciano de Investigación Biosanitaria (IMIB), 30120 El Palmar, Spain. mcolisan@um.es.
Instituto Murciano de Investigación Biosanitaria · ESUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caffeic acid derivatives represent promising lead compounds in the search for tyrosinase inhibitors to be used in the treatment of skin local hyperpigmentation associated to an overproduction or accumulation of melanin. We recently reported the marked inhibitory activity of a conjugate of caffeic acid with dihydrolipoic acid, 2-

Indexed as

AgaricalesCaffeic AcidsCell Line, TumorCell SurvivalDose-Response Relationship, DrugEnzyme InhibitorsHumansInhibitory Concentration 50MelaninsMelanomaMonophenol MonooxygenasePyronesSkin Lightening PreparationsThioctic AcidTyrosine 3-Monooxygenasecaffeic acid methyl esterCaffeic Acidsdihydrolipoic acidEnzyme Inhibitorskojic acidMelaninsMonophenol MonooxygenasePyronesSkin Lightening PreparationsThioctic AcidTyrosine 3-Monooxygenasecaffeic aciddepigmenting agentdihydrolipoic aciddopa oxidaseinhibition mechanismskin lighteningtyrosinase

Identifiers

PMID30042336
PMCPMC6121902
OpenAlexW2884011816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.