Evidence map›Paper›PMID 30042334›Full record

ReviewNutrients2018

Development of Vitamin D Toxicity from Overcorrection of Vitamin D Deficiency: A Review of Case Reports.

Kornelia Galior, Stefan Grebe, Ravinder Singh

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  17. Too much vitamin D? a drug safety review.Reviews in endocrine & metabolic disorders · 2026
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kornelia GaliorDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA. Galior.Kornelia@mayo.edu.
Stefan GrebeDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA. Grebe.Stefan@mayo.edu.
Ravinder SinghDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA. Singh.Ravinder@mayo.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past two decades, vitamin D level measurements have become some of the most frequently ordered tests in the laboratory. This increase is due to a growing awareness of widespread vitamin D deficiency and scientific data suggesting the beneficial effects of vitamin D in various diseases. A literature search was carried out in PubMed for cases reporting vitamin D intoxication and overdose. Thirteen articles were included in this review. Intoxication was severe in the reported cases. Patients presented with serum vitamin D concentrations ranging between 150 and 1220 ng/mL and serum calcium concentrations between 11.1 and 23.1 mg/dL. Most of the reported patients showed symptoms of vitamin D toxicity such as vomiting, dehydration, pain, and loss of appetite. The underlying causes included manufacturing errors, overdosing by patients or prescribers, and combinations of these factors. Our literature search highlights the fact that even though vitamin D intoxication is rare, it does occur and therefore patients and prescribers should be more cognizant of the potential dangers of vitamin D overdose.

Indexed as

CalciumDietary SupplementsDrug OverdoseHumansVitamin DVitamin D DeficiencyCalciumVitamin Dhypercalcemiavitamin D overdosevitamin D toxicity

Identifiers

PMID30042334
PMCPMC6115827

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.