Evidence map›Paper›PMID 30042306›Full record

ArticleBiomedicines2018

GABA Levels in Left and Right Sensorimotor Cortex Correlate across Individuals.

Nicolaas A J Puts, Stefanie Heba, Ashley D Harris, Christopher John Evans, David J McGonigle, Martin Tegenthoff, Tobias Schmidt-Wilcke, Richard A E Edden

Abstract read
In one paragraph

Article in Biomedicines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicolaas A J PutsRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA. nputs1@jhmi.edu.ORCID 0000-0003-1024-1927
Stefanie HebaDepartment of Neurology, BG University Hospital Bergmannsheil, Bürkle de la Camp-Platz 1, 44789 Bochum, Germany. Stefanie.Heba@rub.de.
Ashley D HarrisRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA. ashley.harris2@ucalgary.ca.
Christopher John EvansCUBRIC, School of Psychology, Cardiff University, Cardiff CF24 4HQ, Wales, UK. EvansJ31@cardiff.ac.uk.
David J McGonigleCUBRIC, School of Psychology, Cardiff University, Cardiff CF24 4HQ, Wales, UK. mcgonigled@cardiff.ac.uk.ORCID 0000-0001-9595-6352
Martin TegenthoffDepartment of Neurology, BG University Hospital Bergmannsheil, Bürkle de la Camp-Platz 1, 44789 Bochum, Germany. martin.tegenthoff@ruhr-uni-bochum.de.
Tobias Schmidt-WilckeDepartment of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany. tobias-schmidt-wilcke@t-online.de.
Richard A E EddenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA. raee2@jhu.edu.

Funding

A Multimodal Investigation of Inhibitory Dysfunction in Autism Spectrum DisorderR00MH107719 · NIMH · JOHNS HOPKINS UNIVERSITY · PI PUTS, NICOLAAS · 2018 to 2019
$492k
A Multimodal Investigation of Inhibitory Dysfunction in Autism Spectrum DisorderK99MH107719 · NIMH · JOHNS HOPKINS UNIVERSITY · PI PUTS, NICOLAAS · 2016 to 2017
$165k
NIMH NIH HHS K99 MH107719NIMH NIH HHS R00 MH107719
6 · The paper itself

Abstract

Differences in γ-aminobutyric acid (GABA) levels measured with Magnetic Resonance Spectroscopy have been shown to correlate with behavioral performance over a number of tasks and cortical regions. These correlations appear to be regionally and functionally specific. In this study, we test the hypothesis that GABA levels will be correlated within individuals for functionally related regions-the left and right sensorimotor cortex. In addition, we investigate whether this is driven by bulk tissue composition. GABA measurements using edited MRS data were acquired from the left and right sensorimotor cortex in 24 participants. T1-weighted MR images were also acquired and segmented to determine the tissue composition of the voxel. GABA level is shown to correlate significantly between the left and right regions (

Indexed as

bilateral inhibitionGABAindividual differencesMRSsensorimotor

Identifiers

PMID30042306
PMCPMC6164430

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.