Evidence map›Paper›PMID 30042304›Full record

ArticleMolecules (Basel, Switzerland)2018

Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders.

Hiroki Ishiguro, Yasue Horiuchi, Koichi Tabata, Qing-Rong Liu, Tadao Arinami, Emmanuel S Onaivi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Psychiatric Disorders and Cannabinoid Receptors.Advances in experimental medicine and biology · 2021
    Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Hiroki IshiguroDepartment of Neuropsychiatry and Clinical Ethics, Graduate School of Medical Science, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan. hishiguro@yamanashi.ac.jp.ORCID 0000-0002-1620-7204
Yasue HoriuchiDepartment of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo 156-8506, Japan. horiuchi-ys@igakuken.or.jp.
Koichi TabataDepartment of Neuropsychiatry and Clinical Ethics, Graduate School of Medical Science, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan. tabata-ymn@umin.org.
Qing-Rong LiuNational Institute on Aging-IRP, NIH, Baltimore, MD 21224, USA. qingrong.liu@nih.gov.ORCID 0000-0001-8477-6452
Tadao ArinamiDepartment of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. tadao.arinami@gmail.com.
Emmanuel S OnaiviDepartment of Biology, William Paterson University, Wayne, NJ 07470, USA. Onaivie@wpunj.edu.
University of Yamanashi · JPNational Institute on Aging · USTokyo Metropolitan Institute of Medical Science · JPUniversity of Tsukuba · JPWilliam Paterson University · US

Funding

USE OF AN IN VIVO MODEL SYSTEM TO INVESTIGATE NIDDMZ01AG000214 · NIA · NATIONAL INSTITUTE ON AGING · PI EGAN, JOSEPHINE M · 1991 to 2008
$693k
BEHAVIORAL EFFECTS OF CB2 CANNABINOID RECEPTORS (CB2RS)R15DA032890 · NIDA · WILLIAM PATERSON UNIVERSITY · PI ONAIVI, EMMANUEL S · 2012 to 2012
$352k
Intramural NIH HHS Z01 AG000214Intramural NIH HHS Z99 AG999999NIDA NIH HHS R15 DA032890
6 · The paper itself

Abstract

CB2 cannabinoid receptor (CB2R) gene is associated with depression. We investigated the gene-environment interaction between CB2R function and diverse stressors. First, anxiety-like behavior during chronic-mild-stress (CMS) was evaluated in C57BL/6JJmsSlc mice following treatment with CB2R agonist JWH015 or inverse-agonist AM630. Second, locomotor activity and anxiety-like behavior were measured following exposure to an immune poly I:C stressor. Gene expressions of HPA axis related molecules,

Indexed as

Gene-Environment InteractionAnimalsAnxietyBrain-Derived Neurotrophic FactorCannabinoid Receptor AgonistsCorticotropin-Releasing HormoneDepressionDisease Models, AnimalGene Expression RegulationHippocampusHypothalamo-Hypophyseal SystemImmunologic FactorsIndolesInterleukin-1betaLocomotionMaleBrain-Derived Neurotrophic FactorCannabinoid Receptor AgonistsCnr2 protein, mouseCorticotropin-Releasing HormoneIL1B protein, mouseImmunologic FactorsIndolesInterleukin-1betaiodopravadolineJHW 015NR3C1 protein, mousePoly I-CReceptor, Cannabinoid, CB2Receptors, GlucocorticoidTacrolimus Binding Protein 5Tacrolimus Binding Proteinsanxietycannabinoid CB2 receptorchronic mild stressCnr2depressionendocannabinoidHPA axisneuro-immune signaling

Identifiers

PMID30042304
PMCPMC6114128
OpenAlexW2884378175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.