Evidence map›Paper›PMID 30042232›Full record

ArticleThe Journal of biological chemistry2018

The lateral meningocele syndrome mutation causes marked osteopenia in mice.

Ernesto Canalis, Jungeun Yu, Lauren Schilling, Siu-Pok Yee, Stefano Zanotti

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Role of Notch signaling in corticalization.Journal of endocrinological investigation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Ernesto CanalisFrom the Departments of Orthopaedic Surgery, canalis@uchc.edu.ORCID 0000-0002-9154-952X
Jungeun YuFrom the Departments of Orthopaedic Surgery.
Lauren SchillingFrom the Departments of Orthopaedic Surgery.
Siu-Pok YeeCell Biology.
Stefano ZanottiFrom the Departments of Orthopaedic Surgery.
UConn Health · USInstitute for Musculoskeletal Health · AUNIHR Oxford Musculoskeletal Biomedical Research Centre · GB

Funding

Mechanisms of Notch Action in BoneR01DK045227 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CANALIS, ERNESTO · 1991 to 2018
$4.7M
The Skeleton of Lateral Meningocele SyndromeR01AR072987 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CANALIS, ERNESTO · 2018 to 2023
$2.2M
Role of Notch Signaling in OsteocytesR01AR063049 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CANALIS, ERNESTO · 2013 to 2017
$1.8M
NIAMS NIH HHS R01 AR063049NIAMS NIH HHS R01 AR072987NIDDK NIH HHS R01 DK045227
6 · The paper itself

Abstract

Lateral meningocele syndrome (LMS) is a rare genetic disorder characterized by neurological complications and osteoporosis. LMS is associated with mutations in exon 33 of

Indexed as

Gain of Function MutationAbnormalities, MultipleAnimalsBone Diseases, MetabolicCancellous BoneFemaleMacrophagesMaleMeningoceleMiceOsteoblastsOsteoclastsOsteocytesRANK LigandReceptor, Notch3RANK LigandReceptor, Notch3Tnfsf11 protein, mousebonebone losslateral meningocele syndromeLehman syndromeNotch receptorosteoblastosteoclastosteocyteosteopeniaskeletal abnormalities

Identifiers

PMID30042232
PMCPMC6130932
OpenAlexW2884681152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.