Evidence map›Paper›PMID 30042214›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Rapid diffusion-state switching underlies stable cytoplasmic gradients in the

Youjun Wu, Bingjie Han, Younan Li, Edwin Munro, David J Odde, Erik E Griffin

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Internal feedback circuits among MEX-5, MEX-6, and PLK-1 maintain faithful patterning in theProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. PLK-1 regulates MEX-1 polarization in thebioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Article
  7. Anterior-posterior pattern formation in ciliates.The Journal of eukaryotic microbiology · 2022
    Review
  8. Article
  9. Article
  10. Modeling protein dynamics inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Going with the flow: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Youjun WuDepartment of Biological Sciences, Dartmouth College, Hanover, NH 03755.ORCID 0000-0002-1126-8817
Bingjie HanDepartment of Biological Sciences, Dartmouth College, Hanover, NH 03755.
Younan LiCommittee on Development, Regeneration and Stem Cell Biology, The University of Chicago, Chicago, IL 60637.
Edwin MunroDepartment of Molecular Genetics and Cell Biology, Committee on Development, Regeneration and Stem Cell Biology, The University of Chicago, Chicago, IL 60637.
David J OddeDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455.
Erik E GriffinDepartment of Biological Sciences, Dartmouth College, Hanover, NH 03755; erik.e.griffin@dartmouth.edu.ORCID 0000-0001-9958-2466

Funding

Dynamics and regulation of actomyosin contractility in the C. elegans embryoR01GM098441 · NIGMS · UNIVERSITY OF CHICAGO · PI MUNRO, EDWIN MARSHALL · 2011 to 2020
$2.9M
Mechanisms of Spatial Organization in the CytoplasmR01GM110194 · NIGMS · DARTMOUTH COLLEGE · PI GRIFFIN, ERIK E · 2015 to 2019
$1.6M
TIRFM-imaging system for in vitro and in vivo cell biologyS10OD018046 · OD · DARTMOUTH COLLEGE · PI GLADFELTER, AMY S · 2014 to 2014
$349k
NIGMS NIH HHS R01 GM098441NIGMS NIH HHS R01 GM110194NIH HHS S10 OD018046
6 · The paper itself

Abstract

Protein concentration gradients organize cells and tissues and commonly form through diffusion away from a local source of protein. Interestingly, during the asymmetric division of the

Indexed as

Models, BiologicalAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell PolarityCytoplasmNuclear ProteinsProtein TransportZygoteCaenorhabditis elegans ProteinsMEX-5 protein, C elegansNuclear Proteinspie-1 protein, C elegansC. elegansgradientsMEX-5PIE-1polarity

Identifiers

PMID30042214
PMCPMC6130366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.