Evidence map›Paper›PMID 30042204›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive Leukemias.

Michael W Schmitt, Justin R Pritchard, Scott M Leighow, Bella I Aminov, Lan Beppu, Daniel S Kim, J Graeme Hodgson, Victor M Rivera, Lawrence A Loeb, Jerald P Radich

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Detection of mutations: from Ames test to duplex sequencing.Frontiers in molecular biosciences · 2026
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  9. Review
  10. KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
  11. Article
  12. Review
  13. Resistance mutations in CML and how we approach them.Hematology. American Society of Hematology. Education Program · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Anticancer drug resistance: An update and perspective.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Michael W Schmitt *Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington. mwschmit@uw.edu jrp94@psu.edu.
Justin R Pritchard *ARIAD Pharmaceuticals, Cambridge, Massachusetts. mwschmit@uw.edu jrp94@psu.edu.
Scott M LeighowDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania.
Bella I AminovDepartment of Pathology, University of Washington School of Medicine, Seattle, Washington.
Lan BeppuClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Daniel S KimDepartment of Biostatistics, University of Washington School of Public Health, Seattle, Washington.
J Graeme HodgsonARIAD Pharmaceuticals, Cambridge, Massachusetts.
Victor M RiveraARIAD Pharmaceuticals, Cambridge, Massachusetts.
Lawrence A LoebDepartment of Pathology, University of Washington School of Medicine, Seattle, Washington.
Jerald P RadichClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Fred Hutch Cancer Center · US

Funding

VIRUS-MEDIATED MYELOSUPPRESSIONP01CA018029 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STEPHANIE J LEE · 1985 to 2026
$128.4M
Tumor mutation signaturesP01CA077852 · NCI · UNIVERSITY OF WASHINGTON · PI SIDOROVA, JULIA · 1999 to 2019
$26.0M
RESEARCH TRAINING IN HEMATOLOGYT32HL007093 · NHLBI · UNIVERSITY OF WASHINGTON · PI Janis L Abkowitz · 1985 to 2026
$13.9M
ITSC for Leukemia: Novel Molecular Strategies for NCTN: "Individualized" TherapieU10CA180861 · NCI · OHIO STATE UNIVERSITY · PI BLOOMFIELD, CLARA D, MARCUCCI, GUIDO · 2014 to 2018
$3.4M
Single-Cell Methods for Analysis of Clonal Heterogeneity and Evolution in CancerR01CA175215 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI RADICH, JERALD PATRICK · 2013 to 2017
$3.0M
Validation and Advanced Development of Duplex SequencingR33CA181771 · NCI · UNIVERSITY OF WASHINGTON · PI LOEB, LAWRENCE A · 2014 to 2016
$1.1M
NCI NIH HHS P01 CA018029NCI NIH HHS P01 CA077852NCI NIH HHS R01 CA175215NCI NIH HHS R33 CA181771NCI NIH HHS U10 CA180861NHLBI NIH HHS T32 HL007093
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Philadelphia ChromosomeCell Line, TumorClonal EvolutionDNA Mutational AnalysisDrug Resistance, NeoplasmGenetic HeterogeneityHigh-Throughput Nucleotide SequencingHumansLeukemiaLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMutationPrecursor Cell Lymphoblastic Leukemia-LymphomaPrognosisSequence Analysis, DNA

Identifiers

PMID30042204
PMCPMC6214777
OpenAlexW2884089970

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.