Evidence map›Paper›PMID 30042199›Full record

ArticlemBio2018

Overexpression or Deletion of Ergosterol Biosynthesis Genes Alters Doubling Time, Response to Stress Agents, and Drug Susceptibility in

Somanon Bhattacharya, Brooke D Esquivel, Theodore C White

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 209 citations in OpenAlex.

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  18. Pilocarpine inhibitsMicrobiology spectrum · 2025
    Article
  19. Expression pattern, subcellular localization ofApplied and environmental microbiology · 2025
    Article
  20. Article

53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Somanon BhattacharyaSchool of the Biological Sciences, University of Missouri, Kansas City, Kansas City, Missouri, USA somanon.bhattacharya@stonybrookmedicine.edu whitetc@umkc.edu.ORCID 0000-0002-8562-3877
Brooke D EsquivelSchool of the Biological Sciences, University of Missouri, Kansas City, Kansas City, Missouri, USA.ORCID 0000-0001-7328-4057
Theodore C WhiteSchool of the Biological Sciences, University of Missouri, Kansas City, Kansas City, Missouri, USA somanon.bhattacharya@stonybrookmedicine.edu whitetc@umkc.edu.
University of Missouri–Kansas City · US

Funding

ORAL CANDIDIASIS IN LENTIVIRUS INFECTED MACAQUESR01DE011367 · NIDCR · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI WHITE, THEODORE C. · 1994 to 2007
$2.5M
AIDS Related Oral Candidiasis: Drugs, Sterols, and Fungal CellsR01DE017078 · NIDCR · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI WHITE, THEODORE C. · 2006 to 2010
$2.1M
Azoles and Candida in AIDS - A Whole Cell ResponseR01DE014161 · NIDCR · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI WHITE, THEODORE C. · 2001 to 2004
$1.4M
NIDCR NIH HHS R01 DE011367NIDCR NIH HHS R01 DE014161NIDCR NIH HHS R01 DE017078
6 · The paper itself

Abstract

Ergosterol (ERG) is a critical sterol in the cell membranes of fungi, and its biosynthesis is tightly regulated by 25 known enzymes along the ERG production pathway. The effects of changes in expression of each ERG biosynthesis enzyme in

Indexed as

Genes, FungalAmphotericin BAntifungal AgentsBiosynthetic PathwaysDrug Resistance, FungalErgosterolFluconazoleGene DeletionGene Expression Regulation, FungalSaccharomyces cerevisiaeAmphotericin BAntifungal AgentsErgosterolFluconazoleantifungal drug resistanceergosterol biosynthesisergosterol gene overexpressionergosterol regulationSaccharomyces cerevisiaestress agents

Identifiers

PMID30042199
PMCPMC6058291
OpenAlexW2883719988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.