Evidence map›Paper›PMID 30042182›Full record

ArticleDevelopment (Cambridge, England)2018

Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions.

Xiaolei Liu, Xiaowu Gu, Wanshu Ma, Michael Oxendine, Hyea Jin Gil, George E Davis, Ondine Cleaver, Guillermo Oliver

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Dynamic multispectral NIR/SWIR forJournal of biomedical optics · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Buttons and Zippers: Endothelial Junctions in Lymphatic Vessels.Cold Spring Harbor perspectives in medicine · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Establishment and maintenance of blood-lymph separation.Cellular and molecular life sciences : CMLS · 2019
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xiaolei LiuCenter for Vascular and Developmental Biology, Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Xiaowu GuDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Wanshu MaCenter for Vascular and Developmental Biology, Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Michael OxendineCenter for Vascular and Developmental Biology, Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Hyea Jin GilCenter for Vascular and Developmental Biology, Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
George E DavisDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA.
Ondine CleaverDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-2454-6641
Guillermo OliverCenter for Vascular and Developmental Biology, Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA guillermo.oliver@northwestern.edu.ORCID 0000-0003-3984-7615
Northwestern University · USThe University of Texas Southwestern Medical Center · USUniversity of Missouri · US

Funding

Prox1 in Mammalian LymphangiogenesisR01HL073402 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI OLIVER, GUILLERMO C · 2003 to 2020
$7.3M
Molecular regulation of Rho and Ras family GTPase activity controls vascular lumen formation.R01HL126518 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI CLEAVER, ONDINE B, DAVIS, GEORGE E · 2015 to 2023
$3.1M
Northwestern University Molecular and Translational Cardiovascular Training ProgramT32HL134633 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCNALLY, ELIZABETH M · 2017 to 2021
$1.6M
Priming of vascular tube morphogenesis: Novel role for VEGF and downstreamRhoA activationR01HL136139 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI CLEAVER, ONDINE B, DAVIS, GEORGE E · 2017 to 2020
$1.6M
NHLBI NIH HHS R01 HL073402NHLBI NIH HHS R01 HL126518NHLBI NIH HHS R01 HL136139NHLBI NIH HHS T32 HL134633
6 · The paper itself

Abstract

Although major progress in our understanding of the genes and mechanisms that regulate lymphatic vasculature development has been made, we still do not know how lumen formation and maintenance occurs. Here, we identify the Ras-interacting protein Rasip1 as a key player in this process. We show that lymphatic endothelial cell-specific

Indexed as

AnimalsCarrier Proteinscdc42 GTP-Binding ProteinCytoskeletonEmbryo, MammalianEndothelial CellsIntracellular Signaling Peptides and ProteinsLymphatic VesselsMiceMice, TransgenicTight JunctionsCarrier Proteinscdc42 GTP-Binding ProteinCdc42 protein, mouseIntracellular Signaling Peptides and ProteinsRasip1 protein, mouseEndothelial cell junctionsLumen maintenanceLymphatic endothelial cellsLymphatic valvesMouseRasip1

Identifiers

PMID30042182
PMCPMC6141773
OpenAlexW2884647355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.