Evidence map›Paper›PMID 30042167›Full record

ArticleBioscience reports2018

Effect of 3-nitropropionic acid inducing oxidative stress and apoptosis of granulosa cells in geese.

Bo Kang, Xinxing Wang, Qilin Xu, Yongsheng Wu, Xiaohui Si, Dongmei Jiang

Open access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Neuroprotective Effects ofArchives of Razi Institute · 2025
    Article
  9. Article
  10. Antioxidants (Basel, Switzerland) · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Bo KangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, People's Republic of China.
Xinxing WangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, People's Republic of China.
Qilin XuCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, People's Republic of China.
Yongsheng WuInstitute of Animal Science, Chengdu Academy of Agriculture and Forestry Sciences, Chengdu, People's Republic of China.
Xiaohui SiCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, People's Republic of China.
Dongmei JiangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, People's Republic of China jiangdm@sicau.edu.cn.
Sichuan Agricultural University · CNChengdu Academy of Agriculture and Forestry Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanism of action by which oxidative stress induces granulosa cell apoptosis, which plays a vital role in initiating follicular atresia, is not well understood. In the present study, the effect of 3-nitropropionic acid (3-NPA) on oxidative stress and apoptosis in granulosa cells in geese was investigated. Our results showed that treatment with 3-NPA at 5.0 mmol/l for 24 h increased intracellular reactive oxygen species (ROS) production by 25.4% and decreased granulosa cell viability by 45.5% (

Indexed as

AnimalsApoptosisbcl-2-Associated X ProteinCaspase 3CatalaseCells, CulturedCell SurvivalFemaleGeeseGene Expression RegulationGlutathione PeroxidaseGranulosa CellsNitro CompoundsOxidative StressPropionatesProto-Oncogene Proteins c-bcl-23-nitropropionic acidbcl-2-Associated X ProteinCaspase 3CatalaseGlutathione PeroxidaseNitro CompoundsPropionatesProto-Oncogene Proteins c-bcl-2Reactive Oxygen SpeciesTumor Suppressor Protein p533-nitropropionic acidapoptosisferritin heavy chaingranulosa celloxidative stress

Identifiers

PMID30042167
PMCPMC6131328
OpenAlexW2883871936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.